Slideshows Images Quizzes

5-Htp

font size


What other names is 5-htp known by?

2-Amino-3-(5-Hydroxy-1H-Indol-3-yl)Propanoic Acid, 5 Hydroxy-Tryptophan, 5 Hydroxy-Tryptophane, 5-Hydroxytryptophan, 5-Hydroxytryptophane, 5-Hydroxy L-Tryptophan, 5-Hydroxy L-Tryptophane, 5-Hydroxy Tryptophan, 5-L-Hydroxytryptophan, L-5 HTP, L-5-Hydroxytryptophan, L-5-Hydroxytryptophane, Oxitriptan.

What is 5-htp?

5-HTP (5-Hydroxytryptophan) is a chemical by-product of the protein building block L-tryptophan. It is also produced commercially from the seeds of an African plant known as Griffonia simplicifolia 5-HTP is used for sleep disorders such as insomnia, depression, anxiety, migraine and tension-type headaches, fibromyalgia, obesity, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), attention deficit-hyperactivity disorder (ADHD), seizure disorder, and Parkinson's disease..

Possibly Effective for...

  • Depression. Some clinical research shows that taking 5-HTP by mouth improve symptoms of depression in some people. Some clinical research shows that taking 5-HTP by mouth might be as beneficial as certain prescription antidepressant drugs for improving depression symptoms. In most studies, 150-800 mg daily of 5-HTP was taken. In some cases, higher doses have been used.

Possibly Ineffective for...

  • Down syndrome. Some research shows that giving 5-HTP to infants with Down syndrome might improve muscle and activity. Other research shows that it does not improve muscle or development when taken from infancy until 3-4 years of age. Research also shows that taking 5-HTP along with conventional prescription drugs does improve development, social skills, or language skills.

Insufficient Evidence to Rate Effectiveness for...

  • Alcoholism. Early research shows that taking 5-HTP with D-phenylalanine and L-glutamine for 40 days can reduce alcohol withdrawal symptoms. However, taking 5-HTP with carbidopa daily for one year does not seem to help people stop drinking. The effect of 5-HTP alone for alcoholism is not clear.
  • Alzheimer's disease. Early research suggests that taking 5-HTP by mouth does not help symptoms of Alzheimer's disease.
  • Anxiety. Evidence on the effects of 5-HTP for anxiety is unclear. Early research shows that taking 25-150 mg of 5-HTP by mouth daily along with carbidopa seems to reduce anxiety symptoms in people with anxiety disorders. However, other early research shows that taking higher doses of 5-HTP, 225 mg daily or more, seems to make anxiety worse. Also, taking 60 mg of 5-HTP daily through the vein does not reduce anxiety in people with panic disorders.
  • Nervous system disorder (Cerebellar ataxia). Evidence on the use of 5-HTP for cerebellar ataxia is unclear. Early evidence shows that taking 5 mg/kg of 5-HTP daily for 4 months can decrease nervous system dysfunction. However, other research shows that taking 5-HTP daily for up to one year does not improve symptoms of cerebellar ataxia.
  • Fibromyalgia. Early research suggests that taking 100 mg of 5-HTP by mouth three times daily for 30-90 days might improve pain, tenderness, sleep, anxiety, fatigue, and morning stiffness in people with fibromyalgia.
  • Menopausal symptoms. Early research suggests that taking 150 mg of 5-HTP daily for 4 weeks does not reduce hot flashes in postmenopausal women.
  • Migraine headache. Evidence on the effects of 5-HTP for the prevention or treatment of migraines in adults is unclear. Some studies show that taking 5-HTP daily does not reduce migraines, while other studies show that it might be as beneficial as prescription drugs. 5-HTP does not seem to reduce migraines in children.
  • Obesity. Early research suggests that taking 5-HTP might help reduce appetite, caloric intake, and weight in obese people. Other research suggests that using a specific mouth spray containing 5-HTP and other extracts (5-HTP-Nat Exts, Medestea Biotech S.p.a., Torino, Italy) for 4 weeks increases weight loss by about 41% in overweight postmenopausal women.
  • Parkinson's disease. Early research shows that taking 100-150 mg of 5-HTP by mouth daily with conventional drugs seems to reduce shaking, but these benefits only continue for up to 5 months. Taking larger doses of 5-HTP, 275-1500 mg daily along with carbidopa seems to worsen symptoms.
  • Schizophrenia. Early research suggests that taking 800 mg to 6 grams of 5-HTP daily with carbidopa for 90 days might improve schizophrenia symptoms in some young men.
  • Tension headache. Early research suggests that taking 100 mg of 5-HTP three times daily for 8 weeks does not reduce pain or the length of tension headaches.
  • Heroin withdrawal symptoms. Early research suggests that taking 200 mg of 5-HTP daily for 6 days together with tyrosine, phosphatidylcholine, and L-glutamine, might reduce insomnia and withdrawal symptoms in recovering heroin addicts.
  • Attention deficit-hyperactivity disorder (ADHD).
  • Insomnia.
  • Premenstrual dysphoric disorder (PMDD).
  • Premenstrual syndrome (PMS).
  • Ramsey-Hunt syndrome.
  • Other conditions.
More evidence is needed to rate the effectiveness of 5-HTP for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


Therapeutic Research Faculty copyright

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Emotional Wellness

Get tips on therapy and treatment.

Health Resources
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations

Health Solutions From Our Sponsors