In the event of methoxsalen overdosage, induce emesis and keep the patient in a darkened room for at least 24 hours. Emesis is beneficial only within the first 2 to 3 hours after ingestion of methoxsalen, since maximum blood levels are reached by this time.
- Patients exhibiting idiosyncratic reactions to psoralen compounds.
- Patients possessing a specific history of light sensitive disease states should not initiate methoxsalen therapy. Diseases associated with photosensitivity include lupus erythematosus, porphyria cutanea tarda, erythropoietic protoporphyria, variegate porphyria, xeroderma pigmentosum, and albinism.
- Patients exhibiting melanoma or possessing a history of melanoma.
- Patients exhibiting invasive squamous cell carcinomas.
- Patients with aphakia, because of the significantly increased risk of retinal damage due to the absence of lenses.
Last reviewed on RxList: 12/15/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional 8-MOP Information
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