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In this Article

• What is methoxsalen (8-MOP)?
• What are the possible side effects of methoxsalen (8-MOP)?
• What is the most important information I should know about methoxsalen (8-MOP)?
• What should I discuss with my health care provider before taking methoxsalen (8-MOP)?
• How should I take methoxsalen (8-MOP)?
• What happens if I miss a dose (8-MOP)?
• What happens if I overdose (8-MOP)?
• What should I avoid while taking methoxsalen (8-MOP)?
• What other drugs will affect methoxsalen (8-MOP)?
• Where can I get more information?

What happens if I miss a dose (8-MOP)?

Call your doctor for instructions if you miss your methoxsalen dose or forget to take the medicine within 90 minutes to 2 hours before your scheduled UVA treatment.

The timing of when you take methoxsalen is critical in relation to UVA treatment. Therefore, you may need to reschedule your light therapy appointment if you have not taken methoxsalen at the proper time beforehand.

What happens if I overdose (8-MOP)?

Stay in a dark room and call your doctor at once if you think you have used too much of this medicine. You will be extremely sensitive to light after an overdose, and you may need to seek emergency medical attention.

Overdose symptoms may include nausea, dizziness, or fainting.

What should I avoid while taking methoxsalen (8-MOP)?

Methoxsalen will make your skin more sensitive to sunlight and sunburn may result. Even sunlight shining through a glass window can expose you to harmful UV rays. Avoid exposure to sunlight or artificial UV rays other than your scheduled light therapy treatments.

Before your UVA treatment: Do not expose your skin to sunlight for at least 24 hours before you take methoxsalen. Avoid applying sunscreen to areas of psoriasis that will be treated with UVA therapy.

After your UVA treatment: Do not expose your skin to sunlight for at least 8 hours after your UVA treatment. Wear protective clothing including a hat and gloves. Use a sunscreen with a minimum SPF of 15, and apply it to all uncovered skin areas exposed to light.

What other drugs will affect methoxsalen (8-MOP)?

Tell your doctor about all medications you use now or have used in the past (including those applied to the skin), especially:

• arsenic trioxide (Trisenox);
• anthralin (Drithrocreme, Micanol);
• a bacteriostatic soap;
• coal tar (Betatar Gel, Denorex, Fototar, Ionil T, MG217, Neutrogena T/Gel or T/Derm, Tegrin Medicated Soap, and others);
• griseofulvin (Fulvicin, Grisactin);
• nalidixic acid (NegGram);
• a staining dye such as methylene blue, toluene blue, rose bengal, or methyl orange;
• a sulfa drug (Bactrim, Gantanol, Septra, and others);
• a diuretic (water pill) such as chlorothiazide (Diuril), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic), chlorthalidone (Hygroton, Thalitone), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), and others;
• an antibiotic such as ciprofloxacin (Cipro), ofloxacin (Floxin), norfloxacin (Noroxin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), and others;
• a tetracycline antibiotic such as demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap); or
• medicine to treat a psychiatric disorder, such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), or trifluperazine (Stelazine).

This list is not complete and there may be other drugs that can interact with methoxsalen. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about methoxsalen.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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