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A-Methapred Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 8/5/2016

A-Methapred (methylprednisolone sodium succinate) is an anti-inflammatory steroid used to treat conditions such as arthritis, lupus, dermatitis, Steven's-Johnson Syndrome, asthma, eye inflammation, ulcerative colitis, leukemia, multiple sclerosis, and more. A-Methapred is available in generic form. Common side effects of A-Methapred include:

  • muscle weakness
  • peptic ulcer
  • slow wound healing
  • thinning skin
  • facial redness
  • vertigo
  • headache
  • changes in menstrual cycle
  • increased eye pressure
  • nausea
  • vomiting
  • heartburn
  • dizziness
  • trouble sleeping
  • appetite changes
  • increased sweating
  • acne
  • fluid retention
  • abdominal bloating
  • high blood pressure
  • injection site reactions (pain, redness, swelling)

Dosage recommendations for A-Methapred vary for each individual. Talk to your doctor about your individual dosage recommendation. Cyclosporin can interact with A-Methapred. Tell your doctor all medications you are taking. Do not take A-Methapred while getting vaccinated for smallpox. Prolonged use of A-Methapred may cause optic nerve damage, eye infections, or glaucoma. Caution should be exercised if you take A-Methapred while pregnant or breastfeeding.

Our A-Methapred (methylprednisolone sodium succinate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

A-Methapred FDA Prescribing Information: Side Effects
(Adverse Reactions)


Fluid and Electrolyte Disturbances

Sodium retention, Fluid retention, Congestive heart failure in susceptible patients, Potassium loss, Hypokalemic alkalosis, Hypertension


Muscle weakness, Steroid myopathy, Loss of muscle mass, Severe arthralgia, Vertebral compression fractures, Aseptic necrosis of femoral and humeral heads, Pathologic fracture of long bones, Osteoporosis


Peptic ulcer with possible perforation and hemorrhage, Pancreatitis, Abdominal distention, and Ulcerative esophagitis


Impaired wound healing, Thin fragile skin, Petechiae and ecchymoses, Facial erythema, Increased sweating, May suppress reactions to skin tests


Increased intracranial pressure with papilledema (pseudo-tumor cerebri) usually after treatment, Convulsions, Vertigo, Headache


Development of Cushingoid state, Suppression of growth in children, Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness, Menstrual irregularities, Decreased carbohydrate tolerance, Manifestations of latent diabetes mellitus, Increased requirements for insulin or oral hypoglycemic agents in diabetics


Posterior subcapsular cataracts, Increased intraocular pressure, Glaucoma, Exophthalmos


Negative nitrogen balance due to protein catabolism

The following additional adverse reactions are related to parenteral corticosteroid therapy: Hyperpigmentation or hypopigmentation, Subcutaneous and cutaneous atrophy, Sterile abscess, Anaphylactic reaction with or without circulatory collapse, cardiac arrest, bronchospasm, Urticaria, Nausea and vomiting, Cardiac arrhythmias; hypotension or hypertension

Read the entire FDA prescribing information for A-Methapred (Methylprednisolone Sodium Succinate)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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