Accolate
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Accolate
ACCOLATE®
(zafirlukast) Tablets
DRUG DESCRIPTION
Zafirlukast is a synthetic, selective peptide leukotriene receptor antagonist (LTRA), with the chemical name 4(5-cyclopentyloxy-carbonylamino-1-methyl-indol-3ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide. The molecular weight of zafirlukast is 575.7 and the structural formula is:
 |
The empirical formula is: C31H33N3O6S
Zafirlukast, a fine white to pale yellow amorphous powder, is practically insoluble in water. It is slightly soluble in methanol and freely soluble in tetrahydrofuran, dimethylsulfoxide, and acetone.
ACCOLATE is supplied as 10 and 20 mg tablets for oral administration.
Inactive Ingredients: Film-coated tablets containing croscarmellose sodium, lactose, magnesium stearate, microcrystalline cellulose, povidone, hypromellose, and titanium dioxide.
What are the possible side effects of zafirlukast (Accolate)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- worsening asthma symptoms;
- new or worsening cough, fever, trouble breathing;
- mood or behavior changes, anxiety, depression, sleep problems (insomnia);
- skin rash, bruising, severe tingling, numbness, pain, muscle weakness; or
- nausea, pain in your upper stomach, loss of appetite, flu symptoms, itching, dark...
Read All Potential Side Effects and See Pictures of Accolate »
What are the precautions when taking zafirlukast (Accolate)?
Before taking zafirlukast, tell your doctor or pharmacist if you are allergic to it; or to other leukotriene blockers (e.g., montelukast); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems.
Caution is advised when using this drug in the elderly because they may be more sensitive to the side effects of the drug, especially headache, diarrhea and nausea.
This medication should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor.
This medication passes into breast milk....
Last reviewed on RxList: 8/18/2011
This monograph has been modified to include the generic and brand name in many instances.
Additional Accolate Information
Accolate - User Reviews
Accolate User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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