Accolate (Zafirlukast) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 21, 2012

Accolate

Asthma »

Myths, facts, and statistics about asthma

Before we present the typical symptoms of asthma, we should dispel some common myths about this condition. This is best achieved by conducting a short true or false quiz.

T or F - Asthma is "all in the mind."
T or F - You will "grow out of it."
T or F - Asthma can be cured, so it is not serious and nobody dies from it.
T or F - You are likely to develop asthma if someone in your family has it.
T or F - You can "catch" asthma from someone else who has it.
T or F - Moving to a different location, such as the desert, can cure asthma.
T or F - People with asthma should not exercise.
T or F - Asthma is best controlled when one has an asthma management plan designed by your doctor. This should include the medications used for quick relief as well as maintenance therapy.
T or F - Medications used to treat asthma are habit...

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ACCOLATE®
(zafirlukast) Tablets

DRUG DESCRIPTION

Zafirlukast is a synthetic, selective peptide leukotriene receptor antagonist (LTRA), with the chemical name 4(5-cyclopentyloxy-carbonylamino-1-methyl-indol-3ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide. The molecular weight of zafirlukast is 575.7 and the structural formula is:

ACCOLATE® (zafirlukast) Structural Formula Illustration

The empirical formula is: C₃₁H₃₃N₃O₆S

Zafirlukast, a fine white to pale yellow amorphous powder, is practically insoluble in water. It is slightly soluble in methanol and freely soluble in tetrahydrofuran, dimethylsulfoxide, and acetone.

ACCOLATE is supplied as 10 and 20 mg tablets for oral administration.

Inactive Ingredients: Film-coated tablets containing croscarmellose sodium, lactose, magnesium stearate, microcrystalline cellulose, povidone, hypromellose, and titanium dioxide.

What are the possible side effects of zafirlukast (Accolate)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

worsening asthma symptoms;
mood or behavior changes, anxiety, depression, or thoughts about suicide or hurting yourself;
skin rash, bruising, severe tingling, numbness, pain, muscle weakness; or
nausea, stomach pain, loss of appetite, itching, dark urine,...

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What are the precautions when taking zafirlukast (Accolate)?

Before taking zafirlukast, tell your doctor or pharmacist if you are allergic to it; or to other leukotriene blockers (e.g., montelukast); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems.

Caution is advised when using this drug in the elderly because they may be more sensitive to the side effects of the drug, especially headache, diarrhea and nausea.

This medication should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk....

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Last reviewed on RxList: 8/18/2011
This monograph has been modified to include the generic and brand name in many instances.