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home > drugs a-z list > accolate (zafirlukast) drug center > accolate (zafirlukast) drug - overdosage and contraindications
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Accolate
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- T or F - Asthma is "all in the mind."
- T or F - You will "grow out of it."
- T or F - Asthma can be cured, so it is not serious and nobody dies from it.
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- T or F - Asthma is best controlled when one has an asthma management plan designed by your doctor. This should include the medications used for quick relief as well as maintenance therapy.
- T or F - Medications used to treat asthma are habit...
Accolate
OVERDOSE
No deaths occurred at oral zafirlukast doses of 2000 mg/kg in mice (approximately 210 times the maximum recommended daily oral dose in adults and children on a mg/m² basis), 2000 mg/kg in rats (approximately 420 times the maximum recommended daily oral dose in adults and children on a mg/m² basis), and 500 mg/kg in dogs (approximately 350 times the maximum recommended daily oral dose in adults and children on a mg/m² basis).
Overdosage with ACCOLATE has been reported in four patients surviving reported doses as high as 200 mg. The predominant symptoms reported following ACCOLATE overdose were rash and upset stomach. There were no acute toxic effects in humans that could be consistently ascribed to the administration of ACCOLATE. It is reasonable to employ the usual supportive measures in the event of an overdose; eg, remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive therapy, if required.
CONTRAINDICATIONS
ACCOLATE is contraindicated in patients who are hypersensitive to zafirlukast or any of its inactive ingredients.
ACCOLATE is contraindicated in patients with hepatic impairment including hepatic cirrhosis.
Last reviewed on RxList: 8/18/2011
This monograph has been modified to include the generic and brand name in many instances.
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