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Accuzyme Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 2/23/2016

Accuzyme (papain and urea) enzymatic debriding ointment is used to break down dead skin or tissues in wounds such as bed sores, ulcers, burns, surgical wounds, cysts, and carbuncles. Accuzyme may be available in generic form. Common side effects of Accuzyme include mild stinging or burning of the skin or skin irritation where the medicine is applied. Tell your doctor if you experience side effects of a severe allergic reaction to Accuzyme including rash, hives, itching, difficulty breathing, or swelling.

Apply a dose of Accuzyme directly to the wound, cover with appropriate dressing, secure into place. Daily or twice daily applications are preferred. Accuzyme may interact with hydrogen peroxide applied to the wound area. Tell your doctor all medications and supplements you use. It is unknown if Accuzyme will be harmful to a fetus. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Accuzyme (papain and urea) enzymatic debriding ointment Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Accuzyme FDA Prescribing Information: Side Effects
(Adverse Reactions)


ACCUZYME (papain and urea) Ointment is generally well-tolerated and non-irritating. A transient "burning" sensation may be experienced by a small percentage of patients upon applying ACCUZYME (papain and urea) Ointment. Occasionally, the profuse exudate from enzymatic digestion may irritate the skin. In such cases, more frequent dressing changes will alleviate discomfort until exudate decreases.

Read the entire FDA prescribing information for Accuzyme (Papain and Urea)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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