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ACE Inhibitors (cont.)

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With which drugs do ACE inhibitors interact?

ACE inhibitors have few important interactions with other drugs.

  • Quinapril (Accupril) may reduce the absorption of tetracycline because quinapril (Accupril) contains magnesium which binds to tetracycline in the intestine and prevents its absorption.

  • Combining potassium supplements, salt substitutes (which often contain potassium), or other drugs that increase potassium levels with ACE inhibitors may result in excessive blood potassium levels because ACE inhibitors can further increase potassium to toxic levels.

  • ACE inhibitors may increase blood concentrations of lithium (Eskalith) and possibly increase side effects of lithium.

  • Nonsteroidal antiinflammatory drugs [NSAIDs, for example, aspirin, ibuprofen, indomethacin (Indocin, Indocin IV), and naproxen (Naprosyn, Naprelan)] may reduce the blood pressure-lowering effects of ACE inhibitors.


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