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Acetadote

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OVERDOSE

Single intravenous doses of acetylcysteine at 1000 mg/kg in mice, 2445 mg/kg in rats, 1500 mg/kg in guinea pigs, 1200 mg/kg in rabbits and 500 mg/kg in dogs were lethal. Symptoms of acute toxicity were ataxia, hypoactivity, labored respiration, cyanosis, loss of righting reflex and convulsions.

CONTRAINDICATIONS

Acetadote (acetylcysteine injection) is contraindicated in patients with previous anaphylactoid reactions to acetylcysteine.

Last reviewed on RxList: 2/3/2009
This monograph has been modified to include the generic and brand name in many instances.

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