May 25, 2017

Aciphex Sprinkle

(rabeprazole sodium) delayed-release capsules


The active ingredient in ACIPHEX Sprinkle delayed-release capsules is rabeprazole sodium, which is a proton pump inhibitor. It is a substituted benzimidazole known chemically as 2-[[[4(3-methoxypropoxy)-3-methyl-2-pyridinyl]-methyl]sulfinyl]-1H–benzimidazole sodium salt. It has an empirical formula of C18H20N3NaO3S and a molecular weight of 381.42. Rabeprazole sodium is a white to slightly yellowish-white solid. It is very soluble in water and methanol, freely soluble in ethanol, chloroform, and ethyl acetate and insoluble in ether and n-hexane. The stability of rabeprazole sodium is a function of pH; it is rapidly degraded in acid media, and is more stable under alkaline conditions. The structural figure is: Figure 1

ACIPHEX® SPRINKLE™ (rabeprazole sodium delayed-release capsules) Structural Formula Illustration

ACIPHEX Sprinkle is available for oral administration as 5 mg and 10 mg rabeprazole sodium delayed-release capsules containing enteric coated granules.

ACIPHEX Sprinkle contains granules of rabeprazole sodium in a hard hypromellose capsule. Inactive ingredients are colloidal silicon dioxide, diacetylated monoglycerides, ethylcellulose, hydroxypropyl cellulose, hypromellose phthalate, magnesium oxide, magnesium stearate, mannitol, talc, titanium dioxide, carrageenan, potassium chloride, FD&C Blue No. 2 Aluminum Lake (in the 5 mg capsule), FD&C Yellow, No. 6 (in the 10 mg capsule), and gray printing ink.

Last reviewed on RxList: 8/2/2016
This monograph has been modified to include the generic and brand name in many instances.

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