"The 70,000 diagnostic codes known as ICD-10 made their long and nervously awaited debut in medical practices today.
Claims for any service performed on October 1 and beyond must bear one or more of the new diagnostic codes â€” more nume"...
(corticorelin ovine triflutate) Intravenous Injection
DIAGNOSTIC USE ONLY
ACTHREL® (corticorelin ovine triflutate for injection) is a sterile, nonpyrogenic, lyophilized white cake powder, containing corticorelin ovine triflutate, a trifluoroacetate salt of a synthetic peptide that is used for the determination of pituitary corticotroph responsiveness. Corticorelin ovine has an amino acid sequence identical to ovine corticotropin-releasing hormone (oCRH). Corticorelin ovine is an analogue of the naturally occurring human CRH (hCRH) peptide. Both peptides are potent stimulators of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. ACTH stimulates cortisol production from the adrenal cortex. The structural formula for corticorelin ovine triflutate is described below:
whereas x=4 -8.
The empirical formula of corticorelin ovine is C205H339N59O63S with a molecular weight of 4670.35 Daltons. ACTHREL® for injection is available in vials containing 100 mcg corticorelin ovine (as the trifluoroacetate), 0.88 mg ascorbic acid, 10 mg lactose, and 26 mg cysteine hydrochloride monohydrate. Trace amounts of chloride ion may be present from the manufacturing process. The preparation is intended for intravenous administration.
What are the possible side effects of corticorelin ovine trifluate (Acthrel)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you feel like you might pass out, or if you have:
- a fast heart rate;
- a tight feeling in your chest; or
- if you feel like you need to take deep breaths.
Less serious side effects may include warmth, redness, or tingly feeling in your face, neck, or chest.
This is not a complete list of side effects and others may occur. Tell your...
Last reviewed on RxList: 9/18/2015
This monograph has been modified to include the generic and brand name in many instances.
Additional Acthrel Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Find out what women really need.