July 25, 2016
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Acticlate

"(Reuters) - A baby born with brain damage at a hospital in Oahu, Hawaii, was infected by the Zika virus, U.S. health officials confirmed on Saturday, apparently the first case of the mosquito-borne virus in a birth on U.S. soil.

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Acticlate

ACTICLATE™
(doxycycline hyclate) Tablets, USP

DRUG DESCRIPTION

ACTICLATE™ (doxycycline hyclate USP) Tablets contain doxycycline hyclate, a broad-spectrum antibacterial synthetically derived from oxytetracycline, in an immediate release formulation for oral administration.

The structural formula for doxycycline hyclate is:

ACTICLATE™ (doxycycline hyclate) Structural Formula Illustration

with a molecular formula of (C22H24N2O8, HCl)2• C2H6O• H2O and a molecular weight of 1025.87.

The chemical designation for doxycycline hyclate is:

4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2naphthacenecarboxamide monohydrochloride, compound with ethyl alcohol (2:1), monohydrate.

Doxycycline hyclate is a yellow crystalline powder soluble in water and in solutions of alkali hydroxides and carbonates. Inactive ingredients in the tablet formulation are: microcrystalline cellulose, sodium lauryl sulfate, croscarmellose sodium and magnesium stearate. Film-coating contains: polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, FD&C Blue #1 (75 mg), FD&C Yellow #6 (75 mg), FD&C Blue #2 (150 mg) and yellow iron oxide (150 mg).

Last reviewed on RxList: 8/14/2014
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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