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(doxycycline hyclate) Tablets, USP


ACTICLATE™ (doxycycline hyclate USP) Tablets contain doxycycline hyclate, a broad-spectrum antibacterial synthetically derived from oxytetracycline, in an immediate release formulation for oral administration.

The structural formula for doxycycline hyclate is:

ACTICLATE™ (doxycycline hyclate) Structural Formula Illustration

with a molecular formula of (C22H24N2O8, HCl)2• C2H6O• H2O and a molecular weight of 1025.87.

The chemical designation for doxycycline hyclate is:

4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2naphthacenecarboxamide monohydrochloride, compound with ethyl alcohol (2:1), monohydrate.

Doxycycline hyclate is a yellow crystalline powder soluble in water and in solutions of alkali hydroxides and carbonates. Inactive ingredients in the tablet formulation are: microcrystalline cellulose, sodium lauryl sulfate, croscarmellose sodium and magnesium stearate. Film-coating contains: polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, FD&C Blue #1 (75 mg), FD&C Yellow #6 (75 mg), FD&C Blue #2 (150 mg) and yellow iron oxide (150 mg).

Last reviewed on RxList: 8/14/2014
This monograph has been modified to include the generic and brand name in many instances.

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