November 25, 2015


(interferon gamma-1b) Subcutaneous Injection


ACTIMMUNE (Interferon gamma-1b), an interferon gamma, is a single-chain polypeptide containing 140 amino acids. Production of ACTIMMUNE is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the recombinant protein. Purification of the product is achieved by conventional column chromatography. ACTIMMUNE is a highly purified sterile solution consisting of non-covalent dimers of two identical 16,465 Dalton monomers; with a specific activity of 20 million International Units/mg (2x106 International Units/0.5 mL) which is equivalent to 30 million units/mg.

ACTIMMUNE is a sterile, clear, colorless solution filled in a single-use vial for subcutaneous injection. Each 0.5 mL of ACTIMMUNE contains: 100 mcg (2 million International Units) of interferon gamma-1b formulated in disodium succinate hexahydrate (0.37 mg), mannitol (20 mg), polysorbate 20 (0.05 mg), succinic acid (0.14 mg) and Sterile Water for Injection. Note that the above activity is expressed in International Units (1 million International Units/50 mcg). This is equivalent to what was previously expressed as units (1.5 million units/50 mcg).

What are the possible side effects of interferon gamma-1b (Actimmune)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using interferon gamma-1b and call your doctor at once if you have any of these serious side effects:

  • fever, chills, body aches, flu symptoms;
  • easy bruising or bleeding, unusual weakness;
  • feeling light-headed, fainting;
  • fast or uneven heart rate; or
  • sudden numbness or weakness, especially on one side of the body.

Less serious side effects may...

Read All Potential Side Effects and See Pictures of Actimmune »

What are the precautions when taking interferon gamma 1 b (Actimmune)?

Before using interferon, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., angina, irregular heartbeat, congestive heart failure), liver disease, seizure disorder, blood cell disorders (e.g., anemia, neutropenia, thrombocytopenia).

Children, especially those younger than 1 year, may be at greater risk for effects on the liver while using this drug. The manufacturer recommends regular laboratory tests (liver function tests), especially in children younger than 1...

Read All Potential Precautions of Actimmune »

Last reviewed on RxList: 10/12/2015
This monograph has been modified to include the generic and brand name in many instances.

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