(interferon gamma-1 b)
ACTIMMUNE® (Interferon gamma-1 b), a biologic response modifier, is a single-chain polypeptide containing 140 amino acids. Production of ACTIMMUNE (interferon gamma 1 b) is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. ACTIMMUNE (interferon gamma 1 b) is a highly purified sterile solution consisting of non-covalent dimers of two identical 16,465 dalton monomers; with a specific activity of 20 million International Units (IU)/mg (2x106 IU per 0.5 mL) which is equivalent to 30 million units/mg.
ACTIMMUNE (interferon gamma 1 b) is a sterile, clear, colorless solution filled in a single-use vial for subcutaneous injection. Each 0.5 mL of ACTIMMUNE contains: 100 mcg (2 million IU) of Interferon gamma-1 b formulated in 20 mg mannitol, 0.36 mg sodium succinate, 0.05 mg polysorbate 20 and Sterile Water for Injection. Note that the above activity is expressed in International Units (1 million IU/50mcg). This is equivalent to what was previously expressed as units (1.5 million U/50mcg).
What are the possible side effects of interferon gamma-1b (Actimmune)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using interferon gamma-1b and call your doctor at once if you have any of these serious side effects:
- fever, chills, body aches, flu symptoms;
- easy bruising or bleeding, unusual weakness;
- feeling light-headed, fainting;
- fast or uneven heart rate; or
- sudden numbness or weakness, especially on one side of the body.
Less serious side effects may...
What are the precautions when taking interferon gamma 1 b (Actimmune)?
Before using interferon, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., angina, irregular heartbeat, congestive heart failure), liver disease, seizure disorder, blood cell disorders (e.g., anemia, neutropenia, thrombocytopenia).
Children, especially those younger than 1 year, may be at greater risk for effects on the liver while using this drug. The manufacturer recommends regular laboratory tests (liver function tests), especially in children younger than 1...
Last reviewed on RxList: 2/19/2008
This monograph has been modified to include the generic and brand name in many instances.
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