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Actisite® (tetracycline periodontal) periodontal fiber for periodontal pocket placement consists of a 23 cm (9 inch) monofilament of ethylene/vinyl acetate copolymer, 0.5 mm in diameter, containing 12.7 mg of evenly dispersed tetracycline hydrochloride, USP.Actisite® (tetracycline periodontal) fiber provides continuous release of tetracycline for 10 days.

Actisite (tetracycline periodontal) is an antibiotic originally isolated from Streptomyces aureofaciens. Chemically it is the monohydrochloride of [4S-(4 α,4a α,5a α, 6 ß, 12a α)] -4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12, 12a-pentahydroxy-6-methyl-1,11-dioxo-2- naphthacenecarboxamide.

Empirical Formula: C₂₂H₂₄N₂O₈.HCl.

The chemical structure of tetracycline hydrochloride:

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.