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Actonel

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Actonel

Overdosage
Contraindications

OVERDOSE

Decreases in serum calcium and phosphorus following substantial overdose may be expected in some patients. Signs and symptoms of hypocalcemia may also occur in some of these patients. Milk or antacids containing calcium should be given to bind Actonel and reduce absorption of the drug.

In cases of substantial overdose, gastric lavage may be considered to remove unabsorbed drug. Standard procedures that are effective for treating hypocalcemia, including the administration of calcium intravenously, would be expected to restore physiologic amounts of ionized calcium and to relieve signs and symptoms of hypocalcemia.

Lethality after single oral doses was seen in female rats at 903 mg/kg and male rats at 1703 mg/kg. The minimum lethal dose in mice and rabbits was 4000 mg/kg and 1000 mg/kg, respectively. These values represent 320 to 620 times the 30 mg human dose based on surface area (mg/m² ).

CONTRAINDICATIONS

Actonel is contraindicated in patients with the following conditions:

Last reviewed on RxList: 5/28/2013
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
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Actonel - User Reviews

Actonel User Reviews

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