Actonel with Calcium
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Actonel with Calcium
Decreases in serum calcium and phosphorus following substantial overdose may be expected in some patients. Signs and symptoms of hypocalcemia may also occur in some of these patients. Milk or antacids containing calcium should be given to bind Actonel and reduce absorption of the drug.
In cases of substantial overdose, gastric lavage may be considered to remove unabsorbed drug. Standard procedures that are effective for treating hypocalcemia, including the administration of calcium intravenously, would be expected to restore physiologic amounts of ionized calcium and to relieve signs and symptoms of hypocalcemia.
Lethality after single oral doses was seen in female rats at 903 mg/kg and male rats at 1703 mg/kg. The minimum lethal dose in mice and rabbits was 4000 mg/kg and 1000 mg/kg. These values represent > 1000 times the 35 mg/week human dose based on surface area (mg/m²).
Because of its limited intestinal absorption, overdosage with calcium carbonate is unlikely. However, prolonged use of very high doses can lead to hypercalcemia. Clinical manifestations of hypercalcemia may include anorexia, thirst, nausea, vomiting, constipation, abdominal pain, muscle weakness, fatigue, mental disturbances, polydipsia, polyuria, bone pain, nephrocalcinosis, renal calculi and in severe cases, cardiac arrhythmias.
Treatment: Calcium should be discontinued. Other therapies that may be contributing to the condition, such as thiazide diuretics, lithium, vitamin A, vitamin D and cardiac glycosides should also be discontinued. Gastric emptying of any residual calcium should be considered. Rehydration, and, according to severity, isolated or combined treatment with loop diuretics, bisphosphonates, calcitonin and corticosteroids should also be considered. Serum electrolytes, renal function and vital signs must be monitored.
- Hypocalcemia (see PRECAUTIONS, General)
- Known hypersensitivity to any component of this product
- Inability to stand or sit upright for at least 30 minutes
Last reviewed on RxList: 3/18/2011
Additional Actonel with Calcium Information
- Actonel with Calcium Drug Interactions Center: risedronate-calcium oral
- Actonel with Calcium Side Effects Center
- Actonel with Calcium in detail including Side Effects and Drug Images
- Actonel with Calcium Overview including Precautions
- Actonel with Calcium FDA Approved Prescribing Information including Dosage
Actonel with Calcium - User Reviews
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