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Actoplus MET

Diabetes facts

  • Diabetes is a chronic condition associated with abnormally high levels of sugar (glucose) in the blood.
  • Insulin produced by the pancreas lowers blood glucose.
  • Absence or insufficient production of insulin causes diabetes.
  • The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent).
  • Symptoms of diabetes include increased urine output, thirst and hunger as well as fatigue.
  • Diabetes is diagnosed by blood sugar (glucose) testing.
  • The major complications of diabetes are both acute and chronic.

    • Acutely: dangerously elevated blood sugar, abnormally low blood sugar due to diabetes medications may occur.
    • Chronically: disease of the blood vessels (both small and large) which can damage the eye, kidneys, nerves, and heart may occur

  • Diabetes treatment depends...

Actoplus MET, Actoplus MET XR

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Actoplus MET Drug Center

Medical Editor: John P. Cunha, DO, FACOEP

Actoplus MET (pioglitazone hydrochloride and metformin hydrochloride) is for people with type 2 diabetes who do not use daily insulin injections. It is not for treating type 1 diabetes. Actoplus MET is a combination of 2 oral diabetes medicines. This medication is available in generic form. Common side effects include nausea, vomiting, stomach upset, diarrhea, weakness, sore throat, muscle pain, weight gain, tooth problems or a metallic taste in the mouth.

The dose of Actoplus MET is individualized on the basis of effectiveness and tolerability. The maximum recommended daily dose is pioglitazone 45 mg/metformin 2550 mg. Hyperglycemia (high blood sugar) may result if you take Actoplus MET with drugs that raise blood sugar, such as: isoniazid, diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, seizure medicines, and diet pills, or medicines to treat asthma, colds or allergies. Hypoglycemia (low blood sugar) may result if you take Actoplus MET with drugs that lower blood sugar, such as: alcohol, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or probenecid. It may also interact with furosemide, nifedipine, cimetidine or ranitidine, amiloride or triamterene, digoxin, morphine, procainamide, quinidine, trimethoprim, or vancomycin. Tell your doctor all medications you are taking. During pregnancy, Actoplus MET should be used only when prescribed. Your doctor may direct you to use insulin instead during your pregnancy. This medication can promote ovulation and increase the risk of becoming pregnant. Metformin passes into breast milk in small amounts. It is unknown if pioglitazone passes into breast milk. Consult your doctor before breast-feeding.

Our Actoplus MET (pioglitazone hydrochloride and metformin hydrochloride) Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements, and diseases and conditions articles.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Actoplus MET Prescribing Information: Indications & Dosage

Pioglitazone hydrochloride Structural Formula Illustration

ACTOPLUS MET is a thiazolidinedione and biguanide combination product indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who are already treated with a thiazolidinedione and metformin or who have inadequate glycemic control on a thiazolidinedione alone or metformin alone.

Read the complete drug monograph for Actoplus MET »

What is Patient information?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Actoplus MET Patient Information: Side Effects

Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.

Stop using metformin and pioglitazone and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • feeling short of breath, even with mild exertion;
  • l...

Read the complete patient information for Actoplus MET »

What is Consumer information?

A concise overview of the drug for the patient or caregiver from First DataBank.

Actoplus MET Consumer Information: Uses

This combination medication is used along with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes (non-insulin-dependent diabetes). This medication should not be used to treat type 1 diabetes (insulin-dependent diabetes). Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

Pioglitazone belongs to a class of drugs known as thiazolidinediones or "glitazones". Metformin and pioglitazone work by...

Read the complete consumer information for Actoplus MET »

What is Actoplus MET Consumer Information?

Warnings - Uses - How to Use - Side Effects - Precautions - Drug Interactions and More

Actoplus MET, Actoplus MET XR - User Reviews

Actoplus MET, Actoplus MET XR User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Actoplus MET, Actoplus MET XR sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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