Acuvail (Ketorolac Tromethamine Ophthalmic Solution) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Acuvail

Cataracts »

Facts about cataracts

A cataract is a clouding of the lens of the eye.
Cataracts are extremely common, and most cataracts are a result of the aging process.
Although many cataracts are not significant enough to require treatment, surgical removal of cataracts is usually safe and effective, resulting in improvement of vision.
Cataract surgery should be performed when the visual loss from the cataract significantly impacts the lifestyle of the individual patient.

What is a cataract?

A cataract is an eye disease in which the clear lens of the eye becomes cloudy opaque, causing decrease in vision. Although the word cataract to describe this condition has been part of the English language only since the middle of the 16th century, the eye disease has been recognized and surgically treated since ancient times.

Read the Cataracts article »

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ACUVAIL™
(ketorolac tromethamine) Ophthalmic Solution 0.45%

DRUG DESCRIPTION

ACUVAIL™ (ketorolac tromethamine ophthalmic solution) 0.45% is a member of the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAIDs) for ophthalmic use. Its chemical name is (±)-5-benzoyl-2,3- dihydro-1H-pyrrolizine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1), and its molecular weight is 376.41. Its molecular formula is C₁₉H₂₄N₂O₆. Its chemical structure is:

ACUVAIL™ (ketorolac tromethamine) Structural Formula Illustration

ACUVAIL™ (ketorolac tromethamine ophthalmic solution) solution is supplied as a sterile isotonic aqueous 0.45% preservative-free solution, with a pH of approximately 6.8. ACUVAIL™ solution is a racemic mixture of R-(+) and S-(-)- ketorolac tromethamine. Ketorolac tromethamine may exist in three crystal forms. All forms are equally soluble in water. The pKa of ketorolac is 3.5. This white to off-white crystalline substance discolors on prolonged exposure to light. The osmolality of ACUVAIL™ (ketorolac tromethamine ophthalmic solution) solution is approximately 285 mOsml/kg.

Contains: Active: ketorolac tromethamine 0.45%. Inactives: Carboxymethylcellulose; sodium chloride; sodium citrate dihydrate; and purified water with sodium hydroxide and/or hydrochloric acid to adjust pH.

Last reviewed on RxList: 8/7/2009
This monograph has been modified to include the generic and brand name in many instances.