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(ketorolac tromethamine) Ophthalmic Solution
ACUVAIL® (ketorolac tromethamine ophthalmic solution) 0.45% is a member of the pyrrolopyrrole group of nonsteroidal anti-inflammatory drugs (NSAIDs) for ophthalmic use. Its chemical name is (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1), and its molecular weight is 376.40. Its molecular formula is C19H24N2O6. Its chemical structure is:
ACUVAIL® solution is supplied as a sterile isotonic aqueous 0.45% preservative-free solution, with a pH of approximately 6.8. ACUVAIL® solution contains a racemic mixture of R-(+) and S-(-)-ketorolac tromethamine. Ketorolac tromethamine may exist in three crystal forms. All forms are equally soluble in water. The pKa of ketorolac is 3.5. This white to off-white crystalline substance discolors on prolonged exposure to light. The osmolality of ACUVAIL® solution is approximately 285 mOsml/kg.
Each mL of ACUVAIL® ophthalmic solution contains: Active: ketorolac tromethamine 0.45%. Inactives: carboxymethylcellulose sodium; sodium chloride; sodium citrate dihydrate; and purified water with sodium hydroxide and/or hydrochloric acid to adjust pH.
What are the possible side effects of ketorolac ophthalmic (Acular, Acular LS, Acular PF, Acuvail)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- severe burning, stinging, or itching of your eyes;
- eye pain, redness, or watering;
- vision changes, increased sensitivity to light;
- white patches on your eyes; or
- crusting or drainage from your eyes.
Less serious side effects may include:
- mild burning,...
Last reviewed on RxList: 12/22/2014
This monograph has been modified to include the generic and brand name in many instances.
Additional Acuvail Information
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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