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Clinical experience with ADAGEN® (pegademase bovine) (pegademase bovine) Injection has been limited. The following adverse reactions were reported during clinical trials: headache in one patient and pain at the injection site in two patients.

The following adverse reactions have been identified during post-approval use of ADAGEN® (pegademase bovine) Injection. Because these reactions are reported voluntarily from a very small population, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Hematologic events: hemolytic anemia, auto-immune hemolytic anemia, thrombocythemia

Dermatological events: injection site erythema, urticaria

There are no known drug interactions with ADAGEN® (pegademase bovine) Injection. However, Vidarabine is a substrate for ADA and 2´- of ADA. Thus, the activities of these drugs andis a potent ADAGEN (pegademase bovine) inhibitor® (pegademase bovine) Injection could be substantially altered if they are used in combination with one another.

Last reviewed on RxList: 12/4/2008
This monograph has been modified to include the generic and brand name in many instances.