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Adalat CC

Last reviewed on RxList: 2/6/2017
Adalat Side Effects Center

Last reviewed on RxList 11/07/2016

Adalat (nifedipine) is a calcium channel blocker drug that relaxes (widens) blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload and is used to lower high blood pressure (hypertension) and to treat chest pain (angina). Side effects of Adalat include:

  • headache,
  • dizziness,
  • fatigue,
  • tiredness,
  • drowsiness,
  • flushing (warmth, redness, or tingly feeling under your skin),
  • sleep problems (insomnia),
  • vivid or abnormal dreams,
  • nausea,
  • stomach pain,
  • diarrhea,
  • constipation,
  • rash or itching,
  • joint pain,
  • leg/muscle cramps,
  • increased urination, or
  • sexual problems.

Tell your doctor if you have unlikely but serious side effects of Adalat including:

  • swelling of the ankles or feet,
  • shortness of breath, or
  • unusual weakness or tiredness.

Adalat is taken orally in tablet form. The usual maintenance dose of Adalat is 30 mg to 60 mg once daily. Adalat may interact with azole antifungals, antibiotics, grapefruit, nefazodone, fluoxetine, antiviral drugs, rifampin, rifabutin, phenobarbital, phenytoin, carbamazepine, St. John's Wort, antiarrhythmics, other calcium channel blockers, ACE inhibitors, angiotensin-II blockers, beta blockers, central alpha1 blockers, digoxin, anticoagulants, diuretics, and other drugs. Tell your doctor all medications and supplements you use. It is not known whether nifedipine will be harmful to an unborn baby. Do not take nifedipine without first talking to your doctor if you are pregnant or could become pregnant during treatment. Nifedipine is known to be excreted in human breast milk, and nursing mothers are advised not to breastfeed their babies when taking the drug.

Our Adalat Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Adalat Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • worsening angina;
  • severe constipation and cramps, severe stomach pain or heartburn, coughing up blood;
  • feeling like you might pass out;
  • feeling short of breath, swelling in your hands or feet;
  • fast or pounding heartbeats;
  • numbness or tingly feeling;
  • jaundice (yellowing of the skin or eyes); or
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

Less serious side effects may include:

  • headache, dizziness;
  • drowsiness, tired feeling;
  • nausea, diarrhea mild constipation or stomach pain;
  • sleep problems (insomnia);
  • mild rash or itching;
  • joint pain, leg cramps;
  • warmth, redness, or tingly feeling under your skin; or
  • urinating more than usual.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Adalat (Nifedipine)

Adalat Professional Information

SIDE EFFECTS

Adverse Experiences

The incidence of adverse events during treatment with Adalat CC in doses up to 90 mg daily were derived from multi-center placebo-controlled clinical trials in 370 hypertensive patients. Atenolol 50 mg once daily was used concomitantly in 187 of the 370 patients on Adalat CC and in 64 of the 126 patients on placebo. All adverse events reported during Adalat CC therapy were tabulated independently of their causal relationship to medication.

The most common adverse event reported with Adalat CC was peripheral edema. This was dose related and the frequency was 18% on Adalat CC 30 mg daily, 22% on Adalat CC 60 mg daily and 29% on Adalat CC 90 mg daily versus 10% on placebo.

Other common adverse events reported in the above placebo-controlled trials include:

Adverse Event ADALAT CC (%)
(n=370)
PLACEBO(%)
(n=126)
Headache 19 13
Flushing/heat sensation 4 0
Dizziness 4 2
Fatigue/asthenia 4 4
Nausea 2 1
Constipation 1 0

Where the frequency of adverse events with Adalat CC and placebo is similar, causal relationship cannot be established.

The following adverse events were reported with an incidence of 3% or less in daily doses up to 90 mg:

Body as a Whole/Systemic: chest pain, leg pain

Central Nervous System: paresthesia, vertigo

Dermatologic: rash

Gastrointestinal: constipation

Musculoskeletal: leg cramps

Respiratory: epistaxis, rhinitis

Urogenital: impotence, urinary frequency

Other adverse events reported with an incidence of less than 1.0% were:

Body as a Whole/Systemic: allergic reaction, asthenia, cellulitis, substernal chest pain, chills, facial edema, lab test abnormal, malaise, neck pain, pelvic pain, pain, photosensitivity reaction Cardiovas cular: atrial fibrillation, bradycardia, cardiac arrest, extrasystole, hypotension, migraine, palpitations, phlebitis, postural hypotension, tachycardia, cutaneous angiectases

Central Nervous System: anxiety, confusion, decreased libido, depression, hypertonia, hypesthesia, insomnia, somnolence

Dermatologic: angioedema, petechial rash, pruritus, sweating

Gastrointestinal: abdominal pain, diarrhea, dry mouth, dysphagia, dyspepsia, eructation, esophagitis, flatulence, gastrointestinal disorder, gastrointestinal hemorrhage, GGT increased, gum disorder, gum hemorrhage, vomiting

Hematologic: eosinophilia, lymphadenopathy

Metabolic: gout, weight loss

Musculoskeletal: arthralgia, arthritis, joint disorder, myalgia, myasthenia

Respiratory: dyspnea, increased cough, rales, pharyngitis, stridor

Special Senses : abnormal vision, amblyopia, conjunctivitis, diplopia, eye disorder, eye hemorrhage, tinnitus

Urogenital/Reproductive: dysuria, kidney calculus, nocturia, breast engorgement, polyuria, urogenital disorder, erectile dysfunction (ED)

The following adverse events have been reported rarely in patients given nifedipine in coat core or other formulations: allergenic hepatitis, alopecia, anaphylactic reaction, anemia, arthritis with ANA (+), depression, erythromelalgia, exfoliative dermatitis, fever, gingival hyperplasia, gynecomastia, hyperglycemia, jaundice, leukopenia, mood changes, muscle cramps, nervousness, paranoid syndrome, purpura, shakiness, sleep disturbances, Stevens-Johnson syndrome, syncope, taste perversion, thrombocytopenia, toxic epidermal necrolysis, transient blindness at the peak of plasma level, tremor and urticaria.

Read the entire FDA prescribing information for Adalat (Nifedipine)

Related Resources for Adalat

Read the Adalat User Reviews »

© Adalat Patient Information is supplied by Cerner Multum, Inc. and Adalat Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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