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Adcetris

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Adcetris

Adcetris Patient Information Including Side Effects

Brand Names: Adcetris

Generic Name: brentuximab vedotin (Pronunciation: bren TUX i mab ve DOE tin)

What is brentuximab vedotin (Adcetris)?

Brentuximab vedotin is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Brentuximab vedotin is used to treat Hodgkin's lymphoma or anaplastic large cell lymphoma.

Brentuximab vedotin is given after a stem cell transplant or other cancer medications have been tried without successful treatment.

Brentuximab vedotin may also be used for purposes not listed in this medication guide.

What are the possible side effects of brentuximab vedotin (Adcetris)?

Some people receiving a brentuximab vedotin injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel nauseated, itchy, or if you have a fever, chills, cough, or trouble breathing during the infusion. Infusion reactions often occur within the first 24 hours after the start of your brentuximab vedotin infusion.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, chest tightness, trouble breathing; swelling of your face, lips, tongue, or throat.

Brentuximab vedotin increases the risk of a serious viral infection of the brain that can lead to disability or death. This risk is higher if you have a weak immune system or are receiving certain medicines. Call your doctor right away if you have symptoms such as a change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly.

Call your doctor at once if you have any of these other serious side effects, even if they occur several months after you receive brentuximab vedotin, or after your treatment ends.

  • numbness, weakness, burning pain, tingly feeling, or loss of feeling in your arms or legs;
  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • lower back pain, blood in your urine;
  • pain or burning when you urinate, urinating less than usual or not at all;
  • numbness or tingling around your mouth;
  • muscle weakness, tightness, or contraction, overactive reflexes;
  • fast or slow heart rate, weak pulse, feeling short of breath, confusion, fainting; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • tired feeling;
  • stomach pain, nausea, vomiting;
  • diarrhea, constipation, weight loss;
  • swelling in your hands or feet;
  • mild rash or itching;
  • dry skin, hair loss;
  • headache, dizziness, anxiety;
  • muscle spasm, muscle or joint pain; or
  • night sweats, sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Adcetris (brentuximab vedotin) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about brentuximab vedotin (Adcetris)?

You should not receive brentuximab vedotin if you are allergic to it, or if you are also receiving another cancer medicine called bleomycin (Blenoxane).

Some people receiving a brentuximab vedotin injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel nauseated, itchy, or if you have a fever, chills, cough, or trouble breathing during the injection. Infusion reactions often occur within the first 24 hours after the start of your brentuximab vedotin infusion.

Brentuximab vedotin can lower blood cells that help your body fight infections and help your blood clot. Your blood may need to be tested often. Avoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding injury. Tell your doctor at once if you develop signs of infection.

While using brentuximab vedotin, you may need frequent blood tests at your doctor's office.

Brentuximab vedotin may cause a serious viral infection of the brain that can lead to disability or death. Call your doctor right away if you notice any change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly.

Side Effects Centers
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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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