Adcirca (Tadalafil Tablets) Drug Information: Overdosage and Contraindications

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May 23, 2012

Adcirca

Pulmonary Hypertension »

What are pulmonary arteries?

The human body has two major sets of blood vessels that distribute blood from the heart to the body. One set pumps blood from the right heart to the lungs and the other from the left heart to the rest of the body.

The portion of the circulation that distributes oxygen-rich blood from the left side of the heart, throughout the body, is referred to as the systemic circulation.
The blood then returns from the body to the right side of the heart and passes through the lungs to replenish oxygen.
It then returns to the left side of the heart for another round through the systemic circulation.
The portion of the circulation that distributes the blood from the right side of the heart to the lungs is referred to as the pulmonary (lung) circulation.
The pulmonary arteries are the major blood vessels that carry blood from the rig...

Read the Pulmonary Hypertension article »

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OVERDOSE

Single doses up to 500 mg have been given to healthy male subjects, and multiple daily doses up to 100 mg have been given to male patients with erectile dysfunction. Adverse reactions were similar to those seen at lower doses. Doses greater than 40 mg have not been studied in patients with pulmonary arterial hypertension. In cases of overdose, standard supportive measures should be adopted as needed. Hemodialysis contributes negligibly to tadalafil elimination.

CONTRAINDICATIONS

Concomitant Organic Nitrates

Do not use ADCIRCA (tadalafil tablets) in patients who are using any form of organic nitrate, either regularly or intermittently. ADCIRCA (tadalafil tablets) potentiates the hypotensive effect of nitrates. This potentiation is thought to result from the combined effects of nitrates and ADCIRCA (tadalafil tablets) on the nitric oxide/cGMP pathway [see CLINICAL PHARMACOLOGY].

Hypersensitivity Reactions

ADCIRCA (tadalafil tablets) is contraindicated in patients with a known serious hypersensitivity to tadalafil (ADCIRCA (tadalafil tablets) or CIALIS). Hypersensitivity reactions have been reported, including Stevens-Johnson syndrome and exfoliative dermatitis [see ADVERSE REACTIONS].

Last reviewed on RxList: 4/4/2011
This monograph has been modified to include the generic and brand name in many instances.