June 28, 2016

Adenosine

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What other names is Adenosine known by?

Acide 5'-adénylique, Adenine Nucleoside, Adénine Nucléoside, Adenine Riboside, Adénine Riboside, Adenosina, Adénosine, Adenosine Phosphate, Adenosine 5'-Triphosphate Disodium, Adenosine; Adenosine Monophosphate (AMP), Adénosine Monophosphate (AMP); Adenosine-5-monophosphate (A5MP), Adénosine-5-monophosphate (A5MP); Adenosine Diphosphate (ADP), Adénosine Diphosphate (ADP); Adenosine Triphosphate (ATP), Phosphate d'Adénosine.

What is Adenosine?

Adenosine is a chemical that is present in all human cells. It readily combines with phosphate to form various chemical compounds including adenosine monophosphate (AMP) and adenosine triphosphate (ATP). People use it for medicine.

AMP is taken by mouth for treating shingles (herpes zoster infection) and a blood disorder called porphyria cutanea tarda.

ATP is used under the tongue to increase physical energy. It is also given intravenously (by IV) for treating acute kidney failure, multiple organ failure, high blood pressure in lung arteries (pulmonary hypertension), cystic fibrosis, lung cancer, weight loss associated with cancer, and controlling blood pressure during anesthesia and surgery. It is also used for cardiac stress tests.

Healthcare providers give adenosine intravenously for treating surgical pain and nerve pain, pulmonary hypertension, and certain types of irregular heartbeat. It is also given for controlling blood pressure during anesthesia and surgery and for heart tests called cardiac stress tests.

Adenosine is injected into the space around the spinal cord to treat nerve pain.

Adenosine phosphate is given by injection into the muscle (intramuscularly) for treating varicose veins, bursitis, pain and swollen tendons (tendonitis), itchiness, multiple sclerosis (MS), neuropathy, shingles (herpes zoster infection), cold sores and genital herpes (herpes simplex infections), and poor blood circulation.

Effective for...

  • Treating certain kinds of irregular heartbeat (as a prescription-only intravenous medicine).

Possibly Effective for...

  • Treating weight loss in people with advanced cancer. Intravenous ATP seems to improve appetite, food intake, and quality of life in people with advanced non-small-cell lung cancer and other tumors.
  • Wounds, usually in the legs, due to poor circulation (venous stasis ulcers). Intramuscular AMP might relieve fluid retention, itchiness, swelling and redness due to venous stasis ulcers.

Insufficient Evidence to Rate Effectiveness for...

  • Shingles (herpes zoster infection). Early research suggests that AMP given by injection into the muscle might be effective for treating herpes zoster (shingles) infection and for preventing nerve pain that follows these infections. Intramuscular AMP might also be effective for treating other kinds of herpes infections, according to limited research.
  • Lung cancer. Developing studies suggest that ATP is not effective for treating non-small-cell lung cancer.
  • Pain.
  • Other conditions.
More evidence is needed to rate the effectiveness of adenosine for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


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