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(epinephrine injection, USP) Auto-injector

The patient, and caregiver, if possible, should read this information carefully before using Adrenaclick® (a-dren-a-click). You must know how to use Adrenaclick before you have an emergency. This information contains additional details beyond the quick-reference instructions on the Adrenaclick label. This information does not replace talking with your doctor about your medical condition or your treatment.

What is the most important information I should know about Adrenaclick?

Use Adrenaclick and go to your doctor or emergency room right away for more medical treatment.

  • Epinephrine, the active ingredient in Adrenaclick helps treat life-threatening allergic reactions.
  • Make sure to tell your doctor about all your medical conditions and allergies.
  • Always get medical treatment right away after using Adrenaclick.

Since you cannot predict when a life-threatening allergic reaction will occur, carry Adrenaclick with you at all times.

Look at the medicine in your Adrenaclick regularly. If it looks cloudy (has particles in it), is discolored, or if the expiration date has passed, the Adrenaclick should be replaced.

After administration, liquid will remain in the auto-injector that can't be used and should be discarded with the autoinjector as outlined in this Patient Information Leaflet.

What is Adrenaclick?

Adrenaclick is an emergency injection (“shot”) of epinephrine. It is a medicine used for life-threatening allergic reactions such as severe swelling, breathing problems, or loss of blood pressure. Allergic reactions can be caused by stinging and biting insects (bugs), allergy injections, food, medicines, exercise, or unknown causes.

Life-threatening allergic reactions may show up as closing of your breathing airways, wheezing, sneezing, hoarseness, hives, itching, swelling, skin redness, fast heartbeat, weak pulse, feeling very anxious, confusion, stomach pain, losing control of urine or bowel movements (incontinence), faintness, or “passing out” (unconsciousness).

  • Adrenaclick 0.15mg is for patients who weigh 33-66 pounds (15-30 kg).
  • Adrenaclick 0.3mg is for patients who weigh 66 pounds (30 kg) or greater.
  • Use of Adrenaclick must be followed by emergency medical care.
  • Each Adrenaclick unit contains a single dose of epinephrine.

Who should not use Adrenaclick?

There are no absolute contraindications to the use of Adrenaclick in a life-threatening allergic reaction. People with certain medical conditions have a higher chance of getting serious side effects from Adrenaclick.

Tell your doctor about all your medical conditions, but especially if you:

  • have heart disease or high blood pressure
  • have diabetes
  • have thyroid conditions
  • have asthma
  • have depression or other mental disease
  • have Parkinson's disease
  • are pregnant
  • are allergic to any of the ingredients in Adrenaclick

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Some medicines may cause serious side effects if taken while you use Adrenaclick. Some medicines may affect how Adrenaclick works, or Adrenaclick may affect how your other medicines work. Diabetic patients may need to adjust the dose of their diabetes medicines or insulin after using Adrenaclick.

How should I use Adrenaclick?

  • Do NOT remove the gray caps until you are ready to use.
  • Never put thumb, fingers, or hand over the red tip. The needle comes out of the red tip. Accidental injection into hand or feet may result in the loss of blood flow to these areas. If this happens, go immediately to the nearest emergency room.
  • Inject Adrenaclick only into the middle of the outer side of your thigh (upper leg).
  • Hold Adrenaclick in the thigh while slowly counting to 10 to make sure all medicine is delivered.
  • Additional video instructions on the use of Adrenaclick are available at

What should I avoid while using Adrenaclick?

  • Avoid injecting Adrenaclick into your buttock or any other part of your body, otherthan the middle of the outer side of your thigh (upper leg).
  • Avoid injecting Adrenaclick into a vein.

What are the possible side effects of Adrenaclick?

Too much epinephrine (Adrenaclick) can cause dangerously high blood pressure, stroke, or death.

If you take certain medicines, you may develop serious life-threatening side effects from the epinephrine in Adrenaclick. Be sure to tell your doctor about all the medicines you take, especially medicines for asthma.

Patients with certain medical conditions, or who take certain medicines, may get more side effects from Adrenaclick, or the side effects may last longer. This includes patients who take certain types of medicines for asthma, allergies, depression, hyperthyroidism, high blood pressure, and heart disease. Patients with heart disease may feel chest pain (angina). Patients with mental disease or Parkinson's disease may have worsening symptoms of their illness. Adrenaclick (epinephrine) can cause the following reactions. Some reactions can be serious. They usually go away with rest.

Common side effects of Adrenaclick include:

  • faster, irregular (wrong) or 'pounding' heartbeat
  • throbbing headache
  • paleness
  • feelings of over excitement, anxiety, or fear
  • weakness or shakiness
  • dizziness
  • nausea and vomiting
  • sweating

These are not all the possible side effects of Adrenaclick. For more information, ask your doctor or pharmacist.

How should I store Adrenadick?

The medicine in Adrenaclick can be damaged by light. Therefore, keep it in the protective carrying case provided. Keep it at room temperature and protect it from freezing. Do not refrigerate.

Keep Adrenaclick with you at all times.

Check your Adrenaclick regularly to be sure:

  • it has not expired
  • the medicine in Adrenaclick is not cloudy, discolored, or has particles in it.

Replace the Adrenaclick if needed.

General information about the safe and effective use of Adrenaclick.

Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use Adrenaclick for a condition for which it was not prescribed. Do not give Adrenaclickto other people, even if they have the same symptoms you have. It may harm them.

This leaflet summarizes the most important information about Adrenaclick. If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information about Adrenaclick that is written for health professionals.

Manufactured for and Distributed by: Amedra Pharmaceuticals LLC, Horsham, PA 19044. Revised April, 2013

Patient Directions for Use

Before Use Make Sure Medicine Is Ready When You Need It

Look at the medicine in the Adrenaclick regularly. If it looks cloudy, is discolored, has particles in it, or if the expiration date has passed, the Adrenaclick should be replaced.

Do NOT remove GRAY caps until you are ready to use the Adrenaclick.

Do NOT remove GRAY caps until you are ready to use - Illustration

The following instructions should be followed for both Adrenaclick 0.15mg and Adrenaclick 0.3mg. Additional video instructions on the use of Adrenaclick are available at


  • Pull off GRAY end cap with the [1]; you will now see a RED tip. Never put thumb, finger, or hand over the RED tip.
  • Pull off GRAY end cap with [2],

Pull off GRAY end cap with - Illustration


  • Put the RED tip against the middle of the outer side of your thigh (upper leg) as shown. It can go through clothes.

Injecting - Illustration

  • Press down hard until the needle enters your thigh (upper leg) through your skin. Hold it in place while slowly counting to 10.
  • Remove the Adrenaclick from your thigh.
  • Check the RED tip. If the needle is exposed you received the dose. If needle is not visible, repeat Step B.

Get emergency medical help right away.

Call 911


  • The remaining liquid that is left after this fixed dose cannot be further administered and should be discarded.
  • Put the autoinjector, needle first, into the carrying case.
  • Put the light gray case top over the non-needle end of the Adrenaclick unit and close the case.
  • Give your used Adrenaclick to a healthcare worker for proper disposal. Do NOT throw away in a regular trash can.

Last reviewed on RxList: 10/3/2013
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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