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Adrenaclick Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Adrenaclick (epinephrine) Auto-injector is a sympathomimetic catecholamine used in the emergency treatment of severe allergic reactions (Type I) including anaphylaxis to stinging or biting insects, allergen immunotherapy, foods, drugs, diagnostic testing substances, and other allergens, as well as anaphylaxis to unknown substances, or exercise-induced anaphylaxis. Adrenaclick is intended for immediate administration in patients with a history of anaphylactic reactions. Common side effects of Adrenaclick include:
- feeling over-excited
- rapid heartbeat (palpitations)
- irregular heartbeat
- pale skin (pallor)
- nausea and vomiting
- headache, or
- breathing difficulties
Adrenaclick is capable of delivering one dose of either 0.15 mg or 0.3 mg (0.15 mL or 0.3 mL) of epinephrine. This dose is available for auto-injection by the patient. Selection of the appropriate Adrenaclick dosage strength is determined according to patient body weight. Adrenaclick may interact with cardiac glycosides, diuretics, antidepressants, monoamine oxidase inhibitors, sodium levothyroxine, antihistamines, beta-blockers, alpha-blockers, ergot alkaloids, and phenothiazines. Tell your doctor all medications and supplements you use. During pregnancy, Adrenaclick should be used only if prescribed. Consult your doctor before breastfeeding.
Our Adrenaclick (epinephrine) Auto-injector Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Adrenaclick FDA Prescribing Information: Side Effects
Due to the lack of randomized, controlled clinical trials of epinephrine for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of epinephrine is difficult to determine. Adverse reactions reported in observational trials, case reports, and studies are listed below.
Common adverse reactions to systemically administered epinephrine include anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; nausea and vomiting; headache, and/or respiratory difficulties. These symptoms occur in some persons receiving therapeutic doses of epinephrine, but are more likely to occur in patients with hypertension or hyperthyroidism [see WARNINGS AND PRECAUTIONS].
Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs [see WARNINGS AND PRECAUTIONS and DRUG INTERACTIONS].
Accidental injection into the digits, hands or feet may result in loss of blood flow to the affected area [see WARNINGS AND PRECAUTIONS].
Adverse events experienced as a result of accidental injections may include increased heart rate, local reactions including injection site pallor, coldness and hypoesthesia or injury at the injection site resulting in bruising, bleeding, discoloration, erythema or skeletal injury.
Lacerations, bent needles, and embedded needles have been reported when Adrenaclick has been injected into the thigh of young children who are uncooperative and kick or move during an injection [see WARNINGS AND PRECAUTIONS].
Injection into the buttock has resulted in cases of gas gangrene [see WARNINGS AND PRECAUTIONS].
Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported following epinephrine injection in the thigh [see WARNINGS AND PRECAUTIONS].
Read the entire FDA prescribing information for Adrenaclick (Epinephrine Injection, USP Auto-injector)
Additional Adrenaclick Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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