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Adrenaclick Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 5/12/2016

Adrenaclick (epinephrine) Auto-injector is a sympathomimetic catecholamine used in the emergency treatment of severe allergic reactions (Type I) including anaphylaxis to stinging or biting insects, allergen immunotherapy, foods, drugs, diagnostic testing substances, and other allergens, as well as anaphylaxis to unknown substances, or exercise-induced anaphylaxis. Adrenaclick is intended for immediate administration in patients with a history of anaphylactic reactions. Common side effects of Adrenaclick include:

  • anxiety
  • apprehensiveness
  • restlessness
  • feeling over-excited
  • fearful
  • tremor
  • shakiness
  • weakness
  • dizziness
  • sweating
  • rapid heartbeat (palpitations)
  • irregular heartbeat
  • pale skin (pallor)
  • nausea and vomiting
  • headache, or
  • breathing difficulties

Adrenaclick is capable of delivering one dose of either 0.15 mg or 0.3 mg (0.15 mL or 0.3 mL) of epinephrine. This dose is available for auto-injection by the patient. Selection of the appropriate Adrenaclick dosage strength is determined according to patient body weight. Adrenaclick may interact with cardiac glycosides, diuretics, antidepressants, monoamine oxidase inhibitors, sodium levothyroxine, antihistamines, beta-blockers, alpha-blockers, ergot alkaloids, and phenothiazines. Tell your doctor all medications and supplements you use. During pregnancy, Adrenaclick should be used only if prescribed. Consult your doctor before breastfeeding.

Our Adrenaclick (epinephrine) Auto-injector Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Adrenaclick FDA Prescribing Information: Side Effects
(Adverse Reactions)


Adverse reactions to epinephrine include transient, moderate anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; nausea and vomiting; headache, and/or respiratory difficulties. These symptoms occur in some persons receiving therapeutic doses of epinephrine, but are more likely to occur in patients with hypertension or hyperthyroidism. Large doses of epinephrine can cause acute hypertension. Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs [see DRUG INTERACTIONS], Rapid rises in blood pressure have produced cerebral hemorrhage, particularly in elderly patients with cardiovascular disease. Angina may occur in patients with coronary artery disease. The potential for epinephrine to produce these types of adverse reactions does not contraindicate its use in an acute, life-threatening allergic reaction.

Read the entire FDA prescribing information for Adrenaclick (Epinephrine Injection, USP Auto-injector)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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