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Adrenalin

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Adrenalin

Indications
Dosage
How Supplied

INDICATIONS

Adrenalin® is available as a single-use 1 mL vial and a multiple-use 30 mL vial. The 1 mL vial is for use intramuscular, subcutaneous, and intraocular use. The 30 mL vial is for intramuscular and subcutaneous use only, and is NOT FOR OPHTHALMIC USE.

Anaphylaxis (Adrenalin® 1 mL Single-Use And 30 mL Multiple-Dose Vials)

Emergency treatment of allergic reactions (Type I), including anaphylaxis, which may result from allergic reactions to insect stings, biting insects, foods, drugs, sera, diagnostic testing substances and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis. The signs and symptoms associated with anaphylaxis include flushing, apprehension, syncope, tachycardia, thready or unobtainable pulse associated with hypotension, convulsions, vomiting, diarrhea and abdominal cramps, involuntary voiding, airway swelling, laryngospasm, bronchospasm, pruritus, urticaria or angioedema, swelling of the eyelids, lips, and tongue.

Induction and Maintenance of Mydriasis during Intraocular Surgery (Adrenalin® 1 mL single-use vial only)

Induction and maintenance of mydriasis during intraocular surgery.

DOSAGE AND ADMINISTRATION

Anaphylaxis (Adrenalin® 1mL Single-Use And 30 Ml Multiple-Dose Vials)

Inject Adrenalin® intramuscularly or subcutaneously into the anterolateral aspect of the thigh. The injection may be repeated every 5 to 10 minutes as necessary. For intramuscular administration, use a needle long enough (at least 1/2 inch to 5/8 inch) to ensure the injection is administered into the muscle. Monitor the patient clinically for the severity of the allergic reaction and potential cardiac effects of the drug, with repeat doses titrated to effect. Do not administer repeated injections at the same site, as the resulting vasoconstriction may cause tissue necrosis.

Inspect visually for particulate matter and discoloration prior to administration. Do not use if the solution is colored or cloudy, or if it contains particulate matter.

Adults and Children 30 kg (66 lbs) or more: 0.3 to 0.5 mg (0.3 mL to 0.5 mL) of undiluted Adrenalin® administered intramuscularly or subcutaneously in the anterolateral aspect of the thigh, up to a maximum of 0.5 mg (0.5 mL) per injection, repeated every 5 to 10 minutes as necessary. Monitor clinically for reaction severity and cardiac effects.

Children less than 30 kg (66 lbs): 0.01 mg/kg (0.01 mL/kg) of undiluted Adrenalin® administered intramuscularly or subcutaneously in the anterolateral aspect of the thigh, up to a maximum of 0.3 mg (0.3 mL), repeated every 5 to 10 minutes as necessary. Monitor clinically for reaction severity and cardiac effects.

Induction And Maintenance Of Mydriasis During Intraocular Surgery (Adrenalin® 1 mL Single-Use Vial Only)

Adrenalin® must be diluted prior to intraocular use. Dilute 1 mL of Adrenalin® 1 mg/mL (1:1000) in 100 to 1000 mL of an ophthalmic irrigation fluid to create an epinephrine concentration of 1:100,000 to 1:1,000,000 (10 mcg/mL to 1 mcg/mL). Use the irrigating solution as needed for the surgical procedure.

After dilution in an ophthalmic irrigating fluid, Adrenalin® may also be injected intracamerally as a bolus dose of 0.1 mL at a dilution of 1:100,000 to 1:400,000 (10 mcg/mL to 2.5 mcg/mL).

Inspect visually for particulate matter and discoloration prior to administration. Do not use if the solution is colored or cloudy, or if it contains particulate matter.

Note: The Adrenalin® 30 mL multiple-dose vial is not for ophthalmic use. USE ONLY THE ADRENALIN 1 ML SINGLE-USE VIAL FOR OPHTHALMIC USE.

HOW SUPPLIED

Dosage Forms And Strengths

Adrenalin® 1 mg/mL (1:1000) epinephrine injection, 1 mL solution in a single-use clear glass vial and 30 mL solution in a multiple-dose amber glass vial.

Storage And Handling

Adrenalin® 1 mL Single-Use Vials

Each carton contains 25 single-use vials containing 1 mL Adrenalin® (epinephrine injection, USP) solution 1 mg/mL (1:1000) in a 3 mL clear glass vial.

NDC 42023-159-25 1 mL vial

Adrenalin® 30 mL Multi-Dose Vials

Each carton contains either 1 multiple-dose vial or 10 multiple-dose vials containing 30 mL Adrenalin® (epinephrine injection, USP) solution 1 mg/mL (1:1000) in a 36 mL amber glass vial.

NDC 42023-168-01 30 mL vial, pack of 1
NDC 42023-168-10 30 mL vial, pack of 10

Vial and contents must be discarded 30 days after initial use.

Store between 20°C to 25°C (68°F to 77°F). (See USP Controlled Room Temperature.) Epinephrine is light sensitive. Protect from light and freezing.

Inspect visually for particulate matter and discoloration prior to administration. Do not use the solution if it is colored or cloudy, or if it contains particulate matter.

Manufactured and Distributed by: JHP Pharmaceuticals, LLC Rochester, MI 48307. Revised: December 2013

Last reviewed on RxList: 1/9/2014
This monograph has been modified to include the generic and brand name in many instances.

Indications
Dosage
How Supplied
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