Flunisolide hemihydrate infused intravenously at doses up to 4000 mcg/kg in mice, rats and dogs (approximately 25, 50 and 170 times, respectively, the maximum recommended daily inhalation dose in adults and approximately 30, 60 and 200 times, respectively, the maximum recommended daily inhalation dose in children on a mg/m² basis) produced no mortality.

In a double-blind, placebo-controlled study, 18 mg of flunisolide hemihydrate was administered via the CFC formulation over a three-hour period (nine times the maximum labeled daily dose) in 94 patients with acute asthma, and no clinically deleterious effects were observed.

AEROSPAN Inhalation Aerosol is contraindicated in the primary treatment of status asthmaticus or other acute episodes of asthma where intensive measures are required.

Hypersensitivity to flunisolide or any of the ingredients of this preparation contraindicates the use of AEROSPAN Inhalation Aerosol.

Last reviewed on RxList: 1/13/2009
This monograph has been modified to include the generic and brand name in many instances.