Afinitor
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Afinitor
AFINITOR
(everolimus) Tablets
DRUG DESCRIPTION
AFINITOR (everolimus), an inhibitor of mTOR, is an antineoplastic agent.
The chemical name of everolimus is (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18- dihydroxy-12-{(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-aza-tricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone.
The molecular formula is C53H83NO14 and the molecular weight is 958.2. The structural formula is:
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AFINITOR is supplied as tablets for oral administration containing 2.5 mg, 5 mg, 7.5 mg, or 10 mg of everolimus together with butylated hydroxytoluene, magnesium stearate, lactose monohydrate, hypromellose, crospovidone, and lactose anhydrous as inactive ingredients.
What are the possible side effects of Afinitor (Afinitor)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using Afinitor and call your doctor at once if you have a serious side effect such as:
- new or worsening cough, wheezing, feeling short of breath;
- stabbing chest pain, cough with yellow or green mucus;
- seizure (convulsions);
- white patches or sores inside your mouth or on your lips;
- swelling, rapid weight gain, urinating less than usual or not at all;
- fever,...
Read All Potential Side Effects and See Pictures of Afinitor »
What are the precautions when taking everolimus tablets (Afinitor)?
Before taking everolimus, tell your doctor or pharmacist if you are allergic to it; or to sirolimus or temsirolimus; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, any recent/current infections, diabetes, high cholesterol/triglyceride levels.
Everolimus can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult...
Last reviewed on RxList: 8/2/2012
This monograph has been modified to include the generic and brand name in many instances.
Additional Afinitor Information
Afinitor - User Reviews
Afinitor User Reviews
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