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Afinitor

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Afinitor

AFINITOR®
(everolimus) Tablets

DRUG DESCRIPTION

AFINITOR (everolimus), an inhibitor of mammalian target of rapamycin (mTOR), is an antineoplastic agent. The chemical name of everolimus is (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-aza-tricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone.

The molecular formula is C53H83NO14 and the molecular weight is 958.2. The structural formula is:

AFINITOR® (everolimus) Structural Formula Illustration

AFINITOR Tablets are supplied for oral administration and contain 2.5 mg, 5 mg, 7.5 mg, or 10 mg of everolimus. The tablets also contain anhydrous lactose, butylated hydroxytoluene, crospovidone, hypromellose, lactose monohydrate, and magnesium stearate as inactive ingredients.

AFINITOR DISPERZ (everolimus tablets for oral suspension) is supplied for oral administration and contains 2 mg, 3 mg, or 5 mg of everolimus. The tablets for oral suspension also contain butylated hydroxytoluene, colloidal silicon dioxide, crospovidone, hypromellose, lactose monohydrate, magnesium stearate, mannitol, and microcrystalline cellulose as inactive ingredients.

What are the possible side effects of Afinitor (Afinitor)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Afinitor and call your doctor at once if you have a serious side effect such as:

  • new or worsening cough, wheezing, feeling short of breath;
  • stabbing chest pain, cough with yellow or green mucus;
  • seizure (convulsions);
  • white patches or sores inside your mouth or on your lips;
  • swelling, rapid weight gain, urinating less than usual or not at all;
  • fever,...

Read All Potential Side Effects and See Pictures of Afinitor »

What are the precautions when taking everolimus tablets (Afinitor)?

Before taking everolimus, tell your doctor or pharmacist if you are allergic to it; or to sirolimus or temsirolimus; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, any recent/current infections, diabetes, high cholesterol/triglyceride levels.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Everolimus can make you more likely to get infections or may worsen any current infections....

Read All Potential Precautions of Afinitor »

Last reviewed on RxList: 7/14/2014
This monograph has been modified to include the generic and brand name in many instances.

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Afinitor - User Reviews

Afinitor User Reviews

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Here is a collection of user reviews for the medication Afinitor sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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