November 26, 2015
Recommended Topic Related To:


"Miriam E. Tucker
Medscape Medical News

The U.S. Food and Drug Administration (FDA) will now require a "for single patient use only" warning on all multidose pen devices used for injectable diabetes medications.

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Excess insulin administration may cause hypoglycemia and hypokalemia [see WARNINGS AND PRECAUTIONS].

Mild episodes of hypoglycemia can usually be treated with oral glucose. Adjustments in drug dosage, meal patterns, or exercise, may be needed.

Severe episodes of hypoglycemia with coma, seizure, or neurologic impairment may be treated with intramuscular / subcutaneous glucagon or concentrated intravenous glucose. After apparent clinical recovery from hypoglycemia, continued observation and additional carbohydrate intake may be necessary to avoid recurrence of hypoglycemia. Hypokalemia must be corrected appropriately.


AFREZZA is contraindicated in patients with the following:

  • During episodes of hypoglycemia
  • Chronic lung disease, such as asthma or chronic obstructive pulmonary disease (COPD), because of the risk of acute bronchospasm [see WARNINGS AND PRECAUTIONS].
  • Hypersensitivity to regular human insulin or any of the AFREZZA excipients [see WARNINGS AND PRECAUTIONS].
  • This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 5/5/2015


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