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Agenerase Oral Solution

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Agenerase Oral Solution

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Agenerase Oral Solution

OVERDOSE

There is no known antidote for AGENERASE. It is not known whether amprenavir can be removed by peritoneal dialysis or hemodialysis. If overdosage occurs, the patient should be monitored for evidence of toxicity and standard supportive treatment applied as necessary.

AGENERASE Oral Solution (amprenavir oral solution) contains large amounts of propylene glycol. In the event of overdosage, monitoring and management of acid-base abnormalities is recommended. Propylene glycol can be removed by hemodialysis.

CONTRAINDICATIONS

Because of the potential risk of toxicity from the large amount of the excipient, propylene glycol, AGENERASE Oral Solution (amprenavir oral solution) is contraindicated in infants and children below the age of 4 years, pregna nt women, patients with hepatic or renal failure, and patients treated with disulfiram or metronidazole (see WARNINGS and PRECAUTIONS).

Coadministration of AGENERASE is contraindicated with drugs that are highly dependent on CYP3A4 for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events. These drugs are listed in Table 6.

Table 6. Drugs That Are Contraindicated With AGENERASE Oral Solution

Drug Class Drugs Within Class That Are CONTRAINDICATED with AGENERASE
Alcohol-dependence treatment Disulfiram
Antibiotic Metronidazole
Ergot derivatives Dihydroergotamine, ergonovine, ergotamine, methylergonovine
GI motility agent Cisapride
Neuroleptic Pimozide
Sedatives/hypnotics Midazolam, triazolam

If AGENERASE Capsules are coadministered with ritonavir capsules, the antiarrhythmic agents flecainide and propafenone are also contraindicated.

AGENERASEis contraindicated in patients with previously demonstrated clinically significant hypersensitivity to any of the components of this product.

Last reviewed on RxList: 7/18/2008
This monograph has been modified to include the generic and brand name in many instances.

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