"A drug candidate developed by researchers at the NIH's National Center for Advancing Translational Sciences (NCATS) and its collaborators to treat sickle cell disease has been acquired by Baxter International's BioScience business. The drug c"...
(anagrelide hydrochloride) Capsules for Oral Administration
AGRYLIN (anagrelide hydrochloride) is a platelet-reducing agent. Its chemical name is 6,7-dichloro-1,5dihydroimidazo[2,1-b]quinazolin-2(3H)-one monohydrochloride monohydrate. The molecular formula is C10H7Cl2N3O•HCl•H2O which corresponds to a molecular weight of 310.55. The structural formula is:
Anagrelide hydrochloride is an off-white powder. It is very slightly soluble in water and sparingly soluble in dimethyl sulfoxide and dimethylformamide.
AGRYLIN is supplied as capsules for oral administration, containing 0.5 mg of anagrelide base (as anagrelide hydrochloride). The capsules also contain anhydrous lactose NF, crospovidone NF, lactose monohydrate NF, magnesium stearate NF, microcrystalline cellulose NF, and povidone NF as inactive ingredients. The capsule shell contains gelatin, titanium dioxide and black iron oxide.
What are the possible side effects of anagrelide (Agrylin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- sudden chest pain or discomfort, rapid breathing, wheezing, dry cough or hack;
- swelling, rapid weight gain, feeling short of breath (even with mild exertion);
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
- sudden numbness or weakness, especially on one side of...
What are the precautions when taking anagrelide (Agrylin)?
Before taking anagrelide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (e.g., heart attack, irregular heartbeat), lung problems, kidney problems, liver problems.
This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.
Anagrelide may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result...
Last reviewed on RxList: 11/14/2014
This monograph has been modified to include the generic and brand name in many instances.
Additional Agrylin Information
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