Agrylin (Anagrelide) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

Agrylin

Deep Vein Thrombosis (DVT) »

Introduction to deep vein thrombosis (DVT)

Arteries have thin muscles within their walls to be able to withstand the pressure of the heart pumping blood to the far reaches of the body. Veins don't have a significant muscle lining, and there is nothing pumping blood back to the heart except physiology. Blood returns to the heart because the body's large muscles squeeze the veins as they contract in their normal activity of moving the body. The normal activities of moving the body returns the blood back to the heart.

There are two types of veins in the leg; superficial veins and deep veins. Superficial veins lie just below the skin and are easily seen on the surface. Deep veins, as their name implies, are located deep within the muscles of the leg. Blood flows from the superficial veins into the deep venous system through small perforator veins. Superficial and perforator veins have one-way valves within them that allow blood to flow only in the direc...

Read the Deep Vein Thrombosis (DVT) article »

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Agrylin

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AGRYLIN®
(anagrelide hydrochloride) Capsules

DRUG DESCRIPTION

Name: AGRYLIN® (anagrelide hydrochloride)
Dosage Form: 0.5 mg capsules for oral administration
Active Ingredient: AGRYLIN® Capsules contain 0.5 mg of anagrelide base (as anagrelide hydrochloride).
Inactive Ingredients: Anhydrous Lactose NF, Crospovidone NF, Lactose Monohydrate NF, Magnesium stearate NF, Microcrystalline cellulose NF, Povidone USP.
Pharmacological Classification: Platelet-reducing agent.
Chemical Name: 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one monohydrochloride monohydrate.
Molecular formula: C₁₀H₇Cl₂N₃O•HCl•H₂O
Molecular weight: 310.55 Structural formula:

AGRYLIN® (anagrelide hydrochloride) Structural Formula Illustration

Appearance: Off-white powder
Solubility:

Water……………………….. Very slightly soluble
Dimethyl Sulfoxide………… Sparingly soluble
Dimethylformamide………... Sparingly soluble

What are the possible side effects of anagrelide (Agrylin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

dry cough, wheezing, night sweats;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;
fast, pounding, or uneven heartbeats;
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill...

Read All Potential Side Effects and See Pictures of Agrylin »

What are the precautions when taking anagrelide (Agrylin)?

Before taking anagrelide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe liver disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (e.g., heart attack, heart failure, irregular heartbeat), lung problems, kidney problems, liver problems.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure...

Read All Potential Precautions of Agrylin »

Last reviewed on RxList: 12/16/2011
This monograph has been modified to include the generic and brand name in many instances.