May 25, 2017
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Akovaz

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Akovaz

AKOVAZ
(ephedrine sulfate) Injection, USP

DRUG DESCRIPTION

Ephedrine is an alpha- and beta-adrenergic agonist and a norepinephrine-releasing agent. AKOVAZ (ephedrine sulfate injection) is a clear, colorless, sterile solution for intravenous injection. It must be diluted before intravenous administration. The chemical name of ephedrine sulfate is (1R,2S)-(-)-2- methylamine-1-phenylpropan-1-ol sulfate, and the molecular weight is 428.5 g/mol. Its structural formula is depicted below:

AKOVAZ (ephedrine sulfate) Structural Formula Illustration

Ephedrine sulfate is freely soluble in water and ethanol, very slighly soluble in chloroform, and practically insoluble in ether. Each mL contains ephedrine sulfate 50 mg (equivalent to 38 mg ephedrine base) in water for injection. The pH is adjusted with sodium hydroxide and/or glacial acetic acid if necesssary. The pH range is 4.5 to 7.0.

Last reviewed on RxList: 5/15/2017
This monograph has been modified to include the generic and brand name in many instances.

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