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(Generic versions may still be available.)
Acute overdosage may produce acute hypotension with other responses attributable to brain and gastrointestinal malfunction (excessive sedation, weakness, bradycardia, dizziness, lightheadedness, constipation, distention, flatus, diarrhea, nausea, vomiting).
In the event of overdosage, symptomatic and supportive measures should be employed. When ingestion is recent, gastric lavage or emesis may reduce absorption. When ingestion has been earlier, infusions may be helpful to promote urinary excretion. Otherwise, management includes special attention to cardiac rate and output, blood volume, electrolyte balance, paralytic ileus, urinary function and cerebral activity.
Sympathomimetic drugs [e.g., levarterenol, epinephrine, ARAMINE* (Metaraminol Bitartrate)] may be indicated. Methyldopa is dialyzable.
The oral LD50 of methyldopa is greater than 1.5 g/kg in both the mouse and the rat.
ALDOMET (methyldopa) is contraindicated in patients:
— on therapy with monoamine oxidase (MAO) inhibitors.
Last reviewed on RxList: 1/31/2005
This monograph has been modified to include the generic and brand name in many instances.
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