Aldoril (Methyldopa-Hydrochlorothiazide) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

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Aldoril

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ALDORIL
(methyldopa and hydrochlorothiazide) Tablet, Film Coated

WARNING

This fixed combination drug is not indicated for initial therapy of hypertension. Hypertension requires therapy titrated to the individual patient. If the fixed combination represents the dosage so determined, its use may be more convenient in patient management. The treatment of hypertension is not static, but must be re-evaluated as conditions in each patient warrant.

DRUG DESCRIPTION

ALDORIL (Methyldopa-Hydrochlorothiazide) combines two antihypertensives: methyldopa and hydrochlorothiazide.

Methyldopa

Methyldopa is an antihypertensive and is the L-isomer of alphamethyldopa. It is levo-3-(3,4-dihydroxyphenyl)-2-methylalanine. Its empirical formula is C₁₀H₁₃NO₄, with a molecular weight of 211.22, and its structural formula is:

Methyldopa is a white to yellowish white, odorless fine powder, and is soluble in water.

Hydrochlorothiazide

Hydrochlorothiazide is a diuretic and antihypertensive. It is the 3,4-dihydro derivative of chlorothiazide. Its chemical name is 6-chloro-3,4-dihydro-2H- 1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C₇H₈ClN₃O₄S₂ and its structural formula is:

Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297.74, which is slightly soluble in water, but freely soluble in sodium hydroxide solution.

ALDORIL (methyldopa-hydrochlorothiazide) is supplied as tablets in four strengths for oral use:

ALDORIL (methyldopa-hydrochlorothiazide) 15, contains 250 mg of methyldopa and 15 mg of hydrochlorothiazide.

ALDORIL (methyldopa-hydrochlorothiazide) 25, contains 250 mg of methyldopa and 25 mg of hydrochlorothiazide.

ALDORIL (methyldopa-hydrochlorothiazide) D30, contains 500 mg of methyldopa and 30 mg of hydrochlorothiazide.

ALDORIL (methyldopa-hydrochlorothiazide) D50, contains 500 mg of methyldopa and 50 mg of hydrochlorothiazide.

Each tablet contains the following inactive ingredients: calcium disodium edetate, calcium phosphate, cellulose, citric acid, colloidal silicon dioxide, ethylcellulose, guar gum, hydroxypropyl methylcellulose, magnesium stearate, propylene glycol, talc, and titanium dioxide. ALDORIL (methyldopa-hydrochlorothiazide) 15 and ALDORIL (methyldopa-hydrochlorothiazide) D30 also contain iron oxide.

What are the possible side effects of methyldopa and hydrochlorothiazide (Aldoril 15, Aldoril 25, Aldoril D30, Aldoril D50)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

dry mouth, thirst, nausea, vomiting;
feeling drowsy, restless, or light-headed;
chest pain, fast or uneven heartbeat;
muscle pain or weakness;
jerky or rolling...

Read All Potential Side Effects and See Pictures of Aldoril »

What are the precautions when taking methyldopa-hydrochlorothiazide (Aldoril)?

Before taking methyldopa with hydrochlorothiazide, tell your doctor or pharmacist if you are allergic to either of them; or if you have any other allergies. This product may contain inactive ingredients (such as sulfites), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney failure (inability to make urine), active liver disease (e.g., hepatitis or cirrhosis), history of liver disease caused by medication.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, low red blood count (e.g., hemolytic anemia), diabetes, a...

Read All Potential Precautions of Aldoril »

Last reviewed on RxList: 4/30/2009
This monograph has been modified to include the generic and brand name in many instances.