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In this Article

• What is laronidase (Aldurazyme)?
• What are the possible side effects of laronidase (Aldurazyme)?
• What is the most important information I should know about laronidase (Aldurazyme)?
• What should I discuss with my healthcare provider before receiving laronidase (Aldurazyme)?
• How should I use laronidase (Aldurazyme)?
• What happens if I miss a dose (Aldurazyme)?
• What happens if I overdose (Aldurazyme)?
• What should I avoid while receiving laronidase (Aldurazyme)?
• What other drugs will affect laronidase (Aldurazyme)?
• Where can I get more information?

What should I discuss with my healthcare provider before receiving laronidase (Aldurazyme)?

You should not use this medication if you are allergic to laronidase.

Before using laronidase, tell your doctor if you are allergic to any drugs.

Your name may need to be listed on a patient registry while you are using this medication. The purpose of this registry is to track the progression of this disorder and the effects that laronidase has on long-term treatment of Hurler syndrome.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether laronidase passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use laronidase (Aldurazyme)?

Laronidase is given as an injection through a needle placed into a vein. You will most likely receive this injection in a clinic or hospital setting. Laronidase is usually given once per week.

The medicine must be given slowly through an IV infusion, and can take up to 4 hours to complete.

Your doctor may also prescribe other medications to help prevent an allergic reaction to laronidase. Take all of your medications as directed.

To be sure this medication is helping your condition and not causing harmful effects, your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments.