"Repeated subcutaneous injections of botulinum toxin A (Botox, Allergan) provides analgesic relief to patients with neuropathic pain, a new randomized controlled trial has shown.
The study showed that two series of injections "...
Overdosage would be manifested by extension of the pharmacological actions of ALFENTA (alfentanil hydrochloride) (see CLINICAL PHARMACOLOGY) as with other potent opioid analgesics. No experience of overdosage with ALFENTA (alfenta (alfenta (alfentanil) nil) nil) was reported during clinical trials. The intravenous LD50 of ALFENTA (alfenta (alfenta (alfentanil) nil) nil) is 43-51 mg/kg in rats, 72-74 mg/kg in mice, 72-82 mg/kg in guinea pigs and 60-88 mg/kg in dogs. Intravenous administration of an opioid antagonist such as naloxone should be employed as a specific antidote to manage respiratory depression.
The duration of respiratory depression following overdosage with ALFENTA (alfenta (alfenta (alfentanil) nil) nil) may be longer than the duration of action of the opioid antagonist. Administration of an opioid antagonist should not preclude immediate establishment of a patent airway, administration of oxygen, and assisted or controlled ventilation as indicated for hypoventilation or apnea. If respiratory depression is associated with muscular rigidity, a neuromuscular blocking agent may be required to facilitate assisted or controlled ventilation. Intravenous fluids and vasoactive agents may be required to manage hemodynamic instability.
ALFENTA (alfenta (alfenta (alfenta (alfentanil) nil) nil) nil hydrochloride) is contraindicated in patients with known hypersensitivity to the drug or known intolerance to other opioid agonists.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 8/14/2008
Additional Alfenta Information
- Alfenta Drug Interactions Center: alfentanil inj
- Alfenta Side Effects Center
- Alfenta FDA Approved Prescribing Information including Dosage
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