November 26, 2015
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"The U.S. Food and Drug Administration today approved Hysingla ER (hydrocodone bitartrate), an extended-release (ER) opioid analgesic to treat pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternat"...




Overdosage would be manifested by extension of the pharmacological actions of ALFENTA (alfentanil hydrochloride) (see CLINICAL PHARMACOLOGY) as with other potent opioid analgesics. No experience of overdosage with ALFENTA (alfenta (alfenta (alfentanil) nil) nil) was reported during clinical trials. The intravenous LD50 of ALFENTA (alfenta (alfenta (alfentanil) nil) nil) is 43-51 mg/kg in rats, 72-74 mg/kg in mice, 72-82 mg/kg in guinea pigs and 60-88 mg/kg in dogs. Intravenous administration of an opioid antagonist such as naloxone should be employed as a specific antidote to manage respiratory depression.

The duration of respiratory depression following overdosage with ALFENTA (alfenta (alfenta (alfentanil) nil) nil) may be longer than the duration of action of the opioid antagonist. Administration of an opioid antagonist should not preclude immediate establishment of a patent airway, administration of oxygen, and assisted or controlled ventilation as indicated for hypoventilation or apnea. If respiratory depression is associated with muscular rigidity, a neuromuscular blocking agent may be required to facilitate assisted or controlled ventilation. Intravenous fluids and vasoactive agents may be required to manage hemodynamic instability.


ALFENTA (alfenta (alfenta (alfenta (alfentanil) nil) nil) nil hydrochloride) is contraindicated in patients with known hypersensitivity to the drug or known intolerance to other opioid agonists.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 8/14/2008


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