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Allegra-D 24 Hour

Last reviewed on RxList: 6/27/2017
Allegra-D 24 Hour Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/27/2017

Allegra-D 24 Hour (fexofenadine hcl 180 and pseudoephendrine hcl 240) is a combination of an antihistamine and a decongestant used to treat sneezing, cough, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold. Allegra-D 24 Hour is available over-the-counter and in generic forms. Common side effects of Allegra-D 24 Hour include:

  • nausea,
  • stomach pain or upset,
  • loss of appetite,
  • constipation,
  • trouble sleeping (insomnia),
  • headache,
  • dizziness,
  • nervousness,
  • dry mouth,
  • skin rash or itching,
  • drowsiness,
  • problems with memory or concentration,
  • restlessness or excitability (especially in children), or
  • ringing in your ears.

Tell your doctor if you have serious side effects of Allegra-D 24 Hour including:

  • fast/irregular/pounding heartbeat,
  • shaking (tremor),
  • mental/mood changes (such as anxiety, confusion, nervousness, restlessness), or
  • problems urinating.

The recommended dose of Allegra-D 24 Hour is one tablet once daily administered on an empty stomach with water for adults and children 12 years of age and older. Allegra-D 24 Hour may interact with medicines to treat high blood pressure, diuretics (water pills), medication to treat irritable bowel syndrome, bladder or urinary medications, aspirin or salicylates, beta-blockers, or antidepressants. Tell your doctor all medications you use. Allegra-D 24 Hour should be used only when prescribed during pregnancy. This medication passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.

Our Allegra-D 24 Hour (fexofenadine hcl 180 and pseudoephendrine hcl 240) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Allegra-D 24 Hour Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • fast, pounding, or uneven heartbeat;
  • confusion, hallucinations, unusual thoughts or behavior;
  • severe dizziness, anxiety, restless feeling, or nervousness;
  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);
  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • dry mouth;
  • nausea, stomach pain, constipation;
  • mild loss of appetite, stomach upset;
  • sleep problems (insomnia);
  • feeling restless or excited (especially in children);
  • skin rash or itching;
  • dizziness, drowsiness;
  • problems with memory or concentration; or
  • ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Allegra-D 24 Hour (Fexofenadine HCl 180 and Pseudoephendrine HCl 240)

Allegra-D 24 Hour Professional Information

SIDE EFFECTS

Fexofenadine Hydrochloride

In a placebo-controlled clinical study in the United States, which included 570 subjects with seasonal allergic rhinitis aged 12 years and older receiving fexofenadine hydrochloride tablets at doses of 120 or 180 mg once daily, adverse events were similar in fexofenadine hydrochloride and placebo-treated subjects. The following table lists adverse experiences that were reported by greater than 2% of subjects treated with fexofenadine hydrochloride tablets at doses of 180 mg once daily and that were more common with fexofenadine hydrochloride than placebo.

Once daily dosing with fexofenadine hydrochloride tablets at rates of greater than 2%

Adverse experience Fexofenadine 180 mg once daily
(n=283)
Placebo
(n=293)
Headache 10.6% 7.5%
Upper Respiratory Tract Infection 3.2% 3.1%
Back Pain 2.8% 1.4%

Events that have been reported during controlled clinical trials involving subjects with seasonal allergic rhinitis at incidences less than 1% and similar to placebo and have been rarely reported during postmarketing surveillance include: insomnia, nervousness, and sleep disorders or paroniria. In rare cases, rash, urticaria, pruritus and hypersensitivity reactions with manifestations such as angioedema, chest tightness, dyspnea, flushing and systemic anaphylaxis have been reported.

Pseudoephedrine Hydrochloride

Pseudoephedrine hydrochloride may cause mild CNS stimulation in hypersensitive patients. Nervousness, excitability, restlessness, dizziness, weakness, or insomnia may occur. Headache, drowsiness, tachycardia, palpitation, pressor activity, cardiac arrhythmias and ischemic colitis have been reported. Sympathomimetic drugs have also been associated with other untoward effects such as fear, anxiety, tenseness, tremor, hallucinations, seizures, pallor, respiratory difficulty, dysuria, and cardiovascular collapse.

Read the entire FDA prescribing information for Allegra-D 24 Hour (Fexofenadine HCl 180 and Pseudoephendrine HCl 240)

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