Allegra-D (Fexofenadine HCl and Pseudoephedrine HCl) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 7, 2012

Allegra-D

Sinus Infection »

Sinus infection facts

Sinus infections are caused by infections from a pathogenic microorganism (virus, bacterium, or fungus), which grows within a sinus and causes intermittent blockage of the sinus ostium.
Most people do not transmit sinus infections; most clinicians agree that except for rare instances, sinus infections are not contagious but arise from mainly viruses and bacteria that, by chance, contaminate a person who sinuses support their proliferation because of minor, and rarely, major abnormalities in the person's sinus tissue (for example, swelling, inflammation, abnormal mucus production, and rarely, facial or nasal trauma).
Sinusitis is inflammation of the air cavities within the passages of the nose. Sinusitis can be caused by infection, but also can be caused by allergies and chemical or particulate irritation of the sinuses.
Sinusitis may be classified in several ways such as acute sinus infec...

Read the Sinus Infection article »

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Allegra-D

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ALLEGRA-D®
12 HOUR (fexofenadine HCl 60 mg and pseudoephedrine HCl 120 mg) Extended-Release Tablets

DRUG DESCRIPTION

ALLEGRA-D® 12 HOUR (fexofenadine hcl and pseudoephedrine hcl) (fexofenadine hydrochloride and pseudoephedrine hydrochloride) Extended-Release Tablets for oral administration contain 60 mg fexofenadine hydrochloride for immediate release and 120 mg pseudoephedrine hydrochloride for extended release. Tablets also contain as excipients: microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, magnesium stearate, carnauba wax, stearic acid, silicon dioxide, hypromellose and polyethylene glycol.

Fexofenadine hydrochloride, one of the active ingredients of ALLEGRA-D (fexofenadine hcl and pseudoephedrine hcl) 12 HOUR, is a histamine H₁-receptor antagonist with the chemical name (±)-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl]-α, α-dimethyl benzeneacetic acid hydrochloride and the following chemical structure:

Fexofenadine HCl Structural Formula Illustration

The molecular weight is 538.13 and the empirical formula is C₃₂H₃₉NO₄•HCl. Fexofenadine hydrochloride is a white to off-white crystalline powder. It is freely soluble in methanol and ethanol, slightly soluble in chloroform and water, and insoluble in hexane. Fexofenadine hydrochloride is a racemate and exists as a zwitterion in aqueous media at physiological pH.

Pseudoephedrine hydrochloride, the other active ingredient of ALLEGRA-D (fexofenadine hcl and pseudoephedrine hcl) 12 HOUR, is an adrenergic (vasoconstrictor) agent with the chemical name [S-(R*,R*)]-α-[1-(methylamino)ethyl]-benzenemethanol hydrochloride and the following chemical structure:

Pseudoephedrine hydrochloride Structural Formula Illustration

The molecular weight is 201.70. The molecular formula is C₁₀H₁₅NO•HCl. Pseudoephedrine hydrochloride occurs as fine, white to off-white crystals or powder, having a faint characteristic odor. It is very soluble in water, freely soluble in alcohol, and sparingly soluble in chloroform.

What are the possible side effects of fexofenadine and pseudoephedrine (Allegra -D 24 Hour, Allegra-D)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

fast, pounding, or uneven heartbeat;
confusion, hallucinations, unusual thoughts or behavior;
severe dizziness, anxiety, restless feeling, or nervousness;
increased blood pressure (severe...

Read All Potential Side Effects and See Pictures of Allegra-D »

What are the precautions when taking fexofenadine hcl and pseudoephedrine hcl (Allegra-D)?

Before taking fexofenadine with pseudoephedrine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: glaucoma (narrow angle type), severe difficulty urinating (urinary retention), severe high blood pressure, severe heart/blood vessel disease (coronary artery disease), experienced serious side effects with decongestants (irregular heart rhythm).

Before using this medication, tell your doctor or pharmacist your medical history, especially of:...

Read All Potential Precautions of Allegra-D »

Last reviewed on RxList: 5/10/2010
This monograph has been modified to include the generic and brand name in many instances.