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(triamcinolone acetonide) Nasal Spray


Triamcinolone acetonide, the active ingredient of AllerNaze (triamcinolone acetonide nasal spray) , is a corticosteroid with the chemical name, 9α-Fluoro-11β,16α, 17, 21­tetrahydroxypregna-1,4-diene-3, 20-dione cyclic 16, 17-acetal with acetone (C24 H31 FO6 ). Its structural formula is:

 AllerNaze (Triamcinolone acetonide) Structural Formula Illustration

Triamcinolone acetonide, USP, is a white crystalline powder, with a molecular weight of 434.51. It, is practically insoluble in water, and sparingly soluble in dehydrated alcohol, in chloroform and in methanol. It has a melting point temperature range between 292° and 294°C.

AllerNaze (triamcinolone acetonide nasal spray) is a metered-dose manual spray pump in an amber polyethylene terephthalate (PET) bottle with 0.05% w/v triamcinolone acetonide in a solution containing citric acid, edetate disodium, polyethylene glycol 3350, propylene glycol, purified water, sodium citrate, and 0.01% benzalkonium chloride as a preservative. AllerNaze (triamcinolone acetonide nasal spray) pH is 5.3.

After initial priming (three sprays) of the AllerNaze (triamcinolone acetonide nasal spray) metered pump delivery system, each spray will deliver 50 mcg of triamcinolone acetonide. If the pump was not used for more than 14 days, reprime with 3 sprays or until a fine mist is observed. Each 15 mL bottle contains 7.5 mg of triamcinolone acetonide to deliver 120 metered sprays. After 120 sprays, the amount of triamcinolone acetonide delivered per spray may not be consistent and the bottle should be discarded.

Last reviewed on RxList: 2/24/2009
This monograph has been modified to include the generic and brand name in many instances.

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