Allernaze (Triamcinolone Acetonide Nasal Spray) Drug Information: Side Effects and Drug Interactions

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May 24, 2012

Allernaze

Allergy Treatment Begins At Home »

Introduction

Avoidance is always the best treatment for allergies regardless of which allergens are the triggers. Interestingly enough, the most effective, least expensive, and simplest options are not always followed. Many people choose medications or vaccinations instead, despite their drawbacks. Fortunately, there are lots of simple methods, both old and new, to help with avoidance. Remember, putting into practice any of these measures can only be helpful in managing your allergies.

The good news is that you really don't have to strip your house down to the bare bones to make it allergy proof. Thorough and regular cleaning generally makes a huge difference in keeping your house as mold and dust free as possible. Patients with asthma or allergic rhinitis that are due to dust mites, molds, or other indoor allergens can feel better by taking these simple measures:

Keep the home cool (between 68 and 72 degrees F);

Read the Allergy Treatment Begins At Home article »

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SIDE EFFECTS

In adequate, well-controlled and uncontrolled studies, 1187 patients have received triamcinolone acetonide solution. The adverse reactions summarized below, are based upon seven placebo controlled clinical trials of 2-6 weeks duration in 847 patients with seasonal or perennial allergic rhinitis (504 patients received 200 mcg or 400 mcg per day of triamcinolone acetonide solution and 343 patients received vehicle placebo). Adverse events reported by 2% or more of patients (regardless of relationship to treatment) who received triamcinolone acetonide solution 200 or 400 mcg once daily and that were more common with triamcinolone acetonide solution than with placebo are displayed in the table below. Overall, the incidence and nature of adverse events with triamcinolone acetonide solution 400 mcg was comparable to that seen with triamcinolone acetonide solution 200 mcg and with vehicle placebo.

ADVERSE EVENTS REPORTED AT A FREQUENCY OF 2% OR GREATER AND MORE COMMON AMONG PATIENTS TREATED WITH triamcinolone acetonide solution THAN PLACEBO REGARDLESS OF RELATIONSHIP TO TREATMENT

ADVERSE EVENTS	200 mcg of triamcinolone acetonide once daily n = 204	400 mcg of triamcinolone acetonide once daily n = 300	Combined (200 and 400 mcg) use of triamcinolone acetonide n = 504	Vehicle Placebo n = 343
BODY AS A WHOLE
Headache	51.0%	44.3%	47.0%	41.1%
Back Pain	7.8%	4.7%	6.0%	3.5%
RESPIRATORY SYSTEM
Pharyngitis	13.7%	10.3%	11.7%	7.9%
Asthma	5.4%	4.3%	4.8%	2.9%
Cough Increased	2.0%	2.7%	2.4%	2.3%
DIGESTIVE SYSTEM
Dyspepsia	4.9%	2.7%	3.6%	2.0%
Nausea	2.0%	3.0%	2.6%	0.6%
Vomiting	1.5%	2.7%	2.2%	1.5%
SPECIAL SENSES
Taste Perversion	7.8%	5.0%	6.2%	2.9%
Conjunctivitis	4.4%	1.3%	2.6%	1.5%
MUSCULOSKELETAL SYSTEM
Myalgia	2.5%	3.3%	3.0%	2.6%

Adverse events reported by 2% or more of patients who received triamcinolone acetonide solution 200 or 400 mcg once daily and that were more common with placebo than with triamcinolone acetonide solution included: application site reaction (e.g. transient nasal burning and stinging), rhinitis, dysmenorrhea, pain (unspecified) and allergic reaction.

The adverse effects related to the irritation of nasal mucous membranes (i.e. application site reaction) did not usually interfere with treatment. In the controlled and uncontrolled studies, approximately 0.3% of patients discontinued because of irritation of nasal mucous membranes.