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Aloprim

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Aloprim

Overdosage
Contraindications

OVERDOSE

Massive overdosing or acute poisoning by ALOPRIM (allopurinol sodium for injection) (allopurinol sodium) for Injection has not been reported.

In mice, the minimal lethal dose is 45 mg/kg given intravenously or 500 mg/kg orally (about 1/3 or 4 times the usual human dose on a mg/m2 basis). Hypoactivity was observed with these doses. In rats, the minimum lethal dose is 100 mg/kg i.v., and 5000 mg/kg orally (about 1.5 and 75 times the usual human dose on a mg/m2 basis).

In the management of overdosage, there is no specific antidote for ALOPRIM (allopurinol sodium) for Injection. There has been no clinical experience in the management of a patient who has taken massive amounts of allopurinol.

Both allopurinol and oxypurinol are dialyzable; however, the usefulness of hemodialysis or peritoneal dialysis in the management of an overdose of ALOPRIM (allopurinol sodium) for Injection is unknown.

CONTRAINDICATIONS

Patients who have developed a severe reaction to allopurinol should not be restarted on the drug .

Last reviewed on RxList: 5/28/2009
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
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