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Massive overdosing or acute poisoning by ALOPRIM (allopurinol sodium for injection) (allopurinol sodium) for Injection has not been reported.

In mice, the minimal lethal dose is 45 mg/kg given intravenously or 500 mg/kg orally (about 1/3 or 4 times the usual human dose on a mg/m² basis). Hypoactivity was observed with these doses. In rats, the minimum lethal dose is 100 mg/kg i.v., and 5000 mg/kg orally (about 1.5 and 75 times the usual human dose on a mg/m² basis).

In the management of overdosage, there is no specific antidote for ALOPRIM (allopurinol sodium) for Injection. There has been no clinical experience in the management of a patient who has taken massive amounts of allopurinol.

Both allopurinol and oxypurinol are dialyzable; however, the usefulness of hemodialysis or peritoneal dialysis in the management of an overdose of ALOPRIM (allopurinol sodium) for Injection is unknown.

Patients who have developed a severe reaction to allopurinol should not be restarted on the drug .

Last reviewed on RxList: 5/28/2009
This monograph has been modified to include the generic and brand name in many instances.