Alphagan-P (Brimonidine Tartrate) Drug Information: Overdosage and Contraindications

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May 24, 2012

Alphagan-P

Glaucoma »

What is glaucoma?

Glaucoma is a disease of the major nerve of vision, called the optic nerve. The optic nerve receives light-generated nerve impulses from the retina and transmits these to the brain, where we recognize those electrical signals as vision. Glaucoma is characterized by a particular pattern of progressive damage to the optic nerve that generally begins with a subtle loss of side vision (peripheral vision). If glaucoma is not diagnosed and treated, it can progress to loss of central vision and blindness.

Glaucoma is usually, but not always, associated with elevated pressure in the eye (intraocular pressure). Generally, it is this elevated eye pressure that leads to damage of the eye (optic) nerve. In some cases, glaucoma may occur in the presence of normal eye pressure. This form of glaucoma is believed to be caused by poor regulation of blood flow to the optic nerve.

How common is glaucoma?

Worldwide, glaucoma...

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OVERDOSE

Very limited information exists on accidental ingestion of brimonidine in adults; the only adverse reaction reported to date has been hypotension. Symptoms of brimonidine overdose have been reported in neonates, infants, and children receiving ALPHAGAN® P (brimonidine tartrate) as part of medical treatment of congenital glaucoma or by accidental oral ingestion (see Use In Specific Populations). Treatment of an oral overdose includes supportive and symptomatic therapy; a patent airway should be maintained.

CONTRAINDICATIONS

Neonates and Infants (under the age of 2 years)

ALPHAGAN® P (brimonidine tartrate) is contraindicated in neonates and infants (under the age of 2 years).

Hypersensitivity Reactions

ALPHAGAN® P (brimonidine tartrate) is contraindicated in patients who have exhibited a hypersensitivity reaction to any component of this medication in the past.

Last reviewed on RxList: 9/14/2010
This monograph has been modified to include the generic and brand name in many instances.