Altace (Ramipril Tablets) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Altace

Congestive Heart Failure »

Congestive heart failure facts

Congestive heart failure (CHF) is a condition in which the heart's function as a pump is inadequate to meet the body's needs.

Many disease processes can impair the pumping efficiency of the heart to cause congestive heart failure.

The symptoms of congestive heart failure vary, but can include fatigue, diminished exercise capacity, shortness of breath, and swelling.

The diagnosis of congestive heart failure is based on knowledge of the individual's medical history, a careful physical examination, and selected laboratory tests.

The treatment of congestive heart failure can include lifestyle modifications, addressing potentially reversible factors, medications, heart transplant, and mechanical therapies.

The course of congestive heart failure in any given patient is extremely variable.

What is congestive h...

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ALTACE
(ramipril)

WARNING

FETAL TOXICITY

When pregnancy is detected, discontinue ALTACE as soon as possible (5.6).
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus (5.6).

DRUG DESCRIPTION

Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105°–112°C. The CAS Registry Number is 87333-19-5. Ramipril's chemical name is (2S,3aS,6aS)-1[(S)-N-[(S)-1-Carboxy-3phenylpropyl] alanyl] octahydrocyclopenta [b]pyrrole-2-carboxylic acid, 1-ethyl ester.

The inactive ingredients present are pregelatinized starch NF, gelatin, and titanium dioxide. The 1.25 mg capsule shell contains yello w iron oxide, the 2.5 mg capsule shell contains D&C yellow #10 and FD&C red #40, the 5 m g capsule shell contains FD&C blue #1 and FD&C red #40, and the 10 mg capsule shell contains FD&C blue #1.

The structural formula for ramipril is:

ALTACE (ramipril) Structural Formula Illustration

Its empirical formula is C₂₃H₃₂N₂O₅ and its molecular weight is 416.5. 5

Ramiprilat, the diacid metabolite of ramipril, is a non-sulfhydryl ACE inhibitor. Ramipril is converted to ramiprilat by hepatic cleavage of the ester group.

What are the possible side effects of ramipril (Altace)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

feeling light-headed, fainting;
urinating less than usual, or not at all;
fever, chills, body aches, flu symptoms;
pale skin, easy bruising or bleeding, unusual weakness;
pounding or uneven heartbeats;
slow heart rate, weak...

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What are the precautions when taking ramipril tablets (Altace)?

Before taking ramipril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), high level of potassium in the blood, collagen vascular disease (such as lupus, scleroderma).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are...

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Last reviewed on RxList: 4/26/2012
This monograph has been modified to include the generic and brand name in many instances.