"What are ACE inhibitors and how do they work?
The class of drugs called angiotensin converting enzyme (ACE) inhibitors, as the class name suggests, reduces the activity of angiotensin converting enzyme. ACE converts angiotensin I pr"...
- When pregnancy is detected, discontinue ALTACE as soon as possible (5.6).
- Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus (5.6).
Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105°–112°C. The CAS Registry Number is 87333-19-5. Ramipril's chemical name is (2S,3aS,6aS)-1[(S)-N-[(S)-1-Carboxy-3phenylpropyl] alanyl] octahydrocyclopenta [b]pyrrole-2-carboxylic acid, 1-ethyl ester.
The inactive ingredients present are pregelatinized starch NF, gelatin, and titanium dioxide. The 1.25 mg capsule shell contains yello w iron oxide, the 2.5 mg capsule shell contains D&C yellow #10 and FD&C red #40, the 5 m g capsule shell contains FD&C blue #1 and FD&C red #40, and the 10 mg capsule shell contains FD&C blue #1.
The structural formula for ramipril is:
Its empirical formula is C23H32N2O5 and its molecular weight is 416.5. 5
Ramiprilat, the diacid metabolite of ramipril, is a non-sulfhydryl ACE inhibitor. Ramipril is converted to ramiprilat by hepatic cleavage of the ester group.
What are the possible side effects of ramipril (Altace)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking ramipril and call your doctor at once if you have a serious side effect such as:
- feeling like you might pass out;
- high potassium level (slow heart rate, weak pulse, muscle weakness, tingly feeling;
- dry mouth, thirst, confusion, swelling, and urinating less than usual or not at all;
- pale skin, dark colored urine, easy bruising or bleeding;
What are the precautions when taking ramipril tablets (Altace)?
Before taking ramipril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), high level of potassium in the blood, collagen vascular disease (such as lupus, scleroderma).
This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are...
Last reviewed on RxList: 4/26/2012
This monograph has been modified to include the generic and brand name in many instances.
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