Altace (Ramipril Tablets) Drug Information: Overdosage and Contraindications

Pill Identifier Search

May 24, 2012

Altace

Heart Attack »

Heart attack facts

A heart attack results when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle and heart muscle dies.
The blood clot that causes the heart attack usually forms at the site of rupture of an atherosclerotic, cholesterol plaque on the inner wall of a coronary artery.
The most common symptom of heart attack is chest pain.
The most common complications of a heart attack are heart failure and ventricular fibrillation.
The risk factors for atherosclerosis and heart attack include elevated cholesterol levels, increased blood pressure, tobacco use, diabetes, male gender, and a family history of heart attacks at an early age.
Heart attacks are diagnosed with electrocardiograms and measurement of cardiac enzymes in blood.
Early reopening of blocked coronary arteries reduces the amount of damage to the heart and im...

Read the Heart Attack article »

« Previous
1
2
3
4
5
6
7
8
9
10
11
12
13
Next »

Altace User Reviews >>

Altace

High Blood Pressure (Hypertension) Slideshow

Take the Salt Quiz!

Lowering Blood Pressure Exercise Tips Pictures

font size

OVERDOSE

Single oral doses of ramipril in rats and mice of 10 g/kg–11 g/kg resulted in significant lethality. In dogs, oral doses as high as 1 g/kg induced only mild gastrointestinal distress. Limited data on human overdosage are available. The most likely clinical manifestations would be symptoms attributable to hypotension.

Laboratory determinations of serum levels of ramipril and its metabolites are not widely available, and such determinations have, in any event, no established role in the management of ramipril overdose. No data are available to suggest physiological maneuvers (e.g., maneuvers to change the pH of the urine) th at might accelerate elimination of ramipril and its metabolites. Similarly, it is not known which, if any, of these substances can be effectively removed from the body by hemodialysis.

Angiotensin II could presumably serve as a specific antagonist-antidote in the setting of ramipril overdose, but angiotensin II is essentially unavailable outside of scattered research facilities. Because the hypot ensive effect of ramipril is achieved through vasodilation and effective hypovolemia, it is reasonable to treat ramipril overdose by inf usion of normal saline solution.

CONTRAINDICATIONS

ALTACE is contraindicated in patients who are hypersensitive to this product or any other ACE inhibitor (e.g., a patient who has experienced angioedema during therapy with any other ACE inhibit or).

Last reviewed on RxList: 4/26/2012
This monograph has been modified to include the generic and brand name in many instances.