Alzheimer's Disease Causes, Stages, and Symptoms (cont.)
William C. Shiel Jr., MD, FACP, FACR
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
In this Article
- Alzheimer's disease facts
- What is Alzheimer's disease?
- What's the difference between Alzheimer's disease and dementia?
- Who develops Alzheimer's disease?
- What are the symptoms of Alzheimer's disease?
- Ten warning signs of Alzheimer's disease
- What causes Alzheimer's disease?
- What are risk factors for Alzheimer's disease?
- How is the diagnosis of Alzheimer's disease made?
- What treatment and management options are available for Alzheimer's disease?
- Cholinesterase inhibitors (ChEIs)
- Partial glutamate antagonists
- Non-drug based treatments
- Treatment of psychiatric symptoms
- What is the prognosis for a person with Alzheimer's disease?
- Caring for the caregiver and Alzheimer's disease resources
- Alzheimer's Disease FAQs
- Find a local Geriatrician in your town
Partial glutamate antagonists
Glutamate is the major excitatory neurotransmitter in the brain. One theory suggests that too much glutamate may be bad for the brain and cause deterioration of nerve cells. Memantine (Namenda) works by partially decreasing the effect of glutamate to activate nerve cells. Studies have demonstrated that some patients on memantine can care for themselves better than patients on sugar pills (placebos). Memantine is approved for treatment of moderate and severe dementia, and studies did not show it was helpful in mild dementia. It is also possible to treat patients with both AchEs and memantine without loss of effectiveness of either medication or an increase in side effects.
Learn more about: Namenda
Non-drug based treatments
Non-medication based treatments include maximizing patients' opportunities for social interaction and participating in activities such as walking, singing, dancing that they can still enjoy. Cognitive rehabilitation, (whereby a patient practices on a computer program for training memory), may or may not be of benefit. Further studies of this method are needed.
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