An overdosage of AMARYL, as with other sulfonylureas, can produce severe hypoglycemia. Mild episodes of hypoglycemia can be treated with oral glucose. Severe hypoglycemic reactions constitute medical emergencies requiring immediate treatment. Severe hypoglycemia with coma, seizure, or neurological impairment can be treated with glucagon or intravenous glucose. Continued observation and additional carbohydrate intake may be necessary because hypoglycemia may recur after apparent clinical recovery [see WARNINGS AND PRECAUTIONS].

AMARYL is contraindicated in patients with a history of a hypersensitivity reaction to:

• Glimepiride or any of the product's ingredients [see WARNINGS AND PRECAUTIONS].

Sulfonamide derivatives: Patients who have developed an allergic reaction to sulfonamide derivatives may develop an allergic reaction to AMARYL. Do not use AMARYL in patients who have a history of an allergic reaction to sulfonamide derivatives.

Reported hypersensitivity reactions include cutaneous eruptions with or without pruritus as well as more serious reactions (e.g. anaphylaxis, angioedema, Stevens-Johnson Syndrome, dyspnea) [see WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS].

Last reviewed on RxList: 2/15/2012
This monograph has been modified to include the generic and brand name in many instances.