" Migraine medications overview
Migraine is a serious, potentially life-threatening neurological disease that affects nearly 36 million Americans, the majority of whom are women. The American Migraine Foundation estimates that one in ev"...
Adverse reactions observed after overdoses of up to 25 mg included increases in blood pressure resulting in lightheadedness, neck tension, tiredness, and loss of coordination. Also, ischemic ECG changes likely due to coronary artery vasospasm have been reported.
The elimination half-life of naratriptan is about 6 hours [see CLINICAL PHARMACOLOGY], and therefore monitoring of patients after overdose with AMERGE should continue for at least 24 hours or while symptoms or signs persist. There is no specific antidote to naratriptan. It is unknown what effect hemodialysis or peritoneal dialysis has on the serum concentrations of naratriptan.
AMERGE is contraindicated in patients with:
- Ischemic coronary artery disease (CAD) (angina pectoris, history of myocardial infarction, or documented silent ischemia) or coronary artery vasospasm, including Prinzmetal's angina [see WARNINGS AND PRECAUTIONS]
- Wolff-Parkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathway disorders [see WARNINGS AND PRECAUTIONS]
- History of stroke or transient ischemic attack (TIA) or history of hemiplegic or basilar migraine because such patients are at a higher risk of stroke [see WARNINGS AND PRECAUTIONS]
- Peripheral vascular disease [see WARNINGS AND PRECAUTIONS]
- Ischemic bowel disease [see WARNINGS AND PRECAUTIONS]
- Uncontrolled hypertension [see WARNINGS AND PRECAUTIONS]
- Recent use (i.e., within 24 hours) of another 5-HT1 agonist, ergotamine-containing medication, ergot-type medication (such as dihydroergotamine or methysergide) [see DRUG INTERACTIONS]
- Hypersensitivity to AMERGE (angioedema and anaphylaxis seen) [see WARNINGS AND PRECAUTIONS]
- Severe renal or hepatic impairment [see Use In Specific Populations, CLINICAL PHARMACOLOGY]
Last reviewed on RxList: 3/21/2016
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