Amikin (Amikacin) Drug Information: Side Effects and Drug Interactions

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May 24, 2012

Amikin

Impetigo »

What is impetigo? What causes impetigo?

Impetigo (pronounced im-puh-TIE-go) is a contagious, superficial infection of the skin caused by staphylococcus (Staph) and streptococcus (Strep) bacteria. Impetigo is more common in children (especially 2- to 5-year-olds) than in adults. Impetigo is most likely to occur in warm and humid environments and is most commonly spread by close contact (such as family members).

What are the types of impetigo, and what are impetigo symptoms and signs? What does impetigo look like?

There are two kinds of impetigo:

Non-bullous impetigo: This is the common form, caused by both Staph and Strep bacteria. This form initially presents as small red papules similar to insect bites. These lesions rapidly evolve to small blisters and then to pustules that finally scab over with a characteristic honey-colored crust. This entire process takes about one week. These lesions often st...

Read the Impetigo article »

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Amikin

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

SIDE EFFECTS

All aminoglycosides have the potential to induce auditory, vestibular, and renal toxicity and neuromuscular blockade (see DESCRIPTION: WARNINGS box). They occur more frequently in patients with present or past history of renal impairment, of treatment with other ototoxic or nephrotoxic drugs, and in patients treated for longer periods and/or with higher doses than recommended.

Neurotoxicity-Ototoxicity: Toxic effects on the eighth cranial nerve can result in hearing loss, loss of balance, or both. Amikacin primarily affects auditory function. Cochlear damage includes high frequency deafness and usually occurs before clinical hearing loss can be detected.

Neurotoxicity-Neuromuscular Blockage: Acute muscular paralysis and apnea can occur following treatment with aminoglycoside drugs.

Nephrotoxicity: Elevation of serum creatinine, albuminuria, presence of red and white cells, casts, azotemia, and oliguria have been reported. Renal function changes are usually reversible when the drug is discontinued.

Other: In addition to those described above, other adverse reactions which have been reported o nrare occasions are skin rash, drug fever, headache, paresthesia, tremor, nausea and vomiting, eosinophilia, arthralgia, anemia, and hypotension.