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Amiloride hydrochloride Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Amiloride Hydrochloride is a diuretic (water pill) used to treat congestive heart failure, high blood pressure (hypertension), and other conditions such as low potassium levels in the blood (hypokalemia). Common side effects include nausea, stomach pain, gas, and mild skin rash.
The recommended dosage of Amiloride Hydrochloride is one 5 mg tablet daily. The dosage may be increased to 10 mg per day, if necessary. Amiloride Hydrochloride may cause high potassium levels in the blood (hyperkalemia). Amiloride Hydrochloride may interact with tacrolimus, cyclosporine, lithium, nonsteroidal anti-inflammatory drugs (NSAIDs), or other diuretics. Tell your doctor all medications you use. Amiloride should be used during pregnancy only if clearly needed. Consult your doctor before using Amiloride Hydrochloride if you are breastfeeding.
Our Amiloride Hydrochloride Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Amiloride hydrochloride FDA Prescribing Information: Side Effects
Amiloride HCl is usually well tolerated and, except for hyperkalemia (serum potassium levels greater than 5.5 mEq liter - see WARNINGS), significant adverse effects have been reported infrequently. Minor adverse reactions were reported relatively frequently (about 20%) but the relationship of many of the reports to amiloride HCl is uncertain and the overall frequency was similar in hydrochlorothiazide treated groups. Nausea/anorexia, abdominal pain, flatulence, and mild skin rash have been reported and probably are related to amiloride. Other adverse experiences that have been reported with amiloride are generally those known to be associated with diuresis, or with the underlying disease being treated.
The adverse reactions for amiloride HCl listed in the following table have been arranged into two groups: (1) incidence greater than one percent; and (2) incidence one percent or less. The incidence for group (1) was determined from clinical studies conducted in the United States (837 patients treated with amiloride HCl). The adverse effects listed in group (2) include reports from the same clinical studies and voluntary reports since marketing. The probability of a causal relationship exists between amiloride HCl and these adverse reactions, some of which have been reported only rarely.
|Incidence > 1%||Incidence ≤ 1%|
|Body as a Whole|
|Abdominal pain||GI disturbance|
|Elevated serum potassium levels ( > 5.5 mEq per liter)**||None|
|Dryness of mouth|
|Muscle cramps||Joint pain|
|Cough||Shortness of breath|
|Increased intraocular pressure|
| *Reactions occurring in 3% to 8% of patients
treated with amiloride HCl. (Those reactions occurring in less than 3%
of the patients are unmarked.)
Causal Relationship Unknown
Other reactions have been reported but occurred under circumstances where a causal relationship could not be established. However, in these rarely reported events, that possibility cannot be excluded. Therefore, these observations are listed to serve as alerting information to physicians.
Read the entire FDA prescribing information for Amiloride hydrochloride (Amiloride Hydrochloride) »
Additional Amiloride Hydrochloride Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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