Aminosyn Electrolytes (Crystalline Amino Acid Solution with Electrolytes) Drug Overview and Uses for Patients and Caregivers at RxList

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May 24, 2012

Aminosyn Electrolytes

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Aminosyn® WITH ELECTROLYTES
Sulfite-Free

A CRYSTALLINE AMINO ACID SOLUTION WITH ELECTROLYTES
Flexible Plastic Container

DRUG DESCRIPTION

Aminosyn® WITH ELECTROLYTES, Sulfite-Free, (a crystalline amino acid solution with electrolytes) is a sterile, nonpyrogenic solution for intravenous infusion. Aminosyn WITH ELECTROLYTES is oxygen sensitive. Three different formulations are available.

Aminosyn Formulations Essential Amino Acids (mg/100 mL)

Aminosyn	3.5% M*	7% WITH ELECTROLYTES	8.5% WITH ELECTROLYTES
Isoleucine	252	510	620
Leucine	329	660	810
Lysine (acetate)**	252	510	624
Methionine	140	280	340
Phenylalanine	154	310	380
Threonine	182	370	460
Tryptophan	56	120	150
Valine	280	560	680
Contains maintenance electrolytes. *Amount cited is for lysine alone and does not include the acetate salt.

Nonessential Amino Acids (mg/100 mL)

Aminosyn	3.5% M*	7% WITH ELECTROLYTES	8.5% WITH ELECTROLYTES
Alanine	448	900	1100
Arginine	343	690	850
Histidine	105	210	260
Proline	300	610	750
Serine	147	300	370
Tyrosine	31	44	44
Glycine	448	900	1100
*Contains maintenance electrolytes.

Essential Amino Acids

Isoleucine	CH₃CH₂CH(CH₃)CH(NH₂)COOH
Leucine	(CH₃)₂CHCH₂CH(NH₂)COOH
Lysine Acetate	H₂N(CH₂)₄CH(NH₂)COOH • CH₃COOH
Methionine	CH₃S(CH₂)₂CH(NH₂)COOH
Phenylalanine	CH₂CH(NH₂)COOH
Threonine	CH₃CH(OH)CH(NH₂)COOH
Tryptophan	CH₂CH(NH₂)COOH
Valine	(CH₃)₂CHCH(NH₂)COOH

Nonessential Amino Acids

Alanine	CH₃CH(NH₂)COOH
Arginine	H₂NC(NH)NH(CH₂)₃CH(NH₂)COOH
Glycine	H₂NCH₂COOH
Histidine	CH₂CH(NH₂)COOH
Proline	COOH
Serine	HOCH₂CH(NH₂)COOH
Tyrosine	CH₂CH(NH₂)COOH

Electrolytes (mEq/Liter)

Aminosyn	3.5% M*	7% WITH ELECTROLYTES	8.5% WITH ELECTROLYTES
Sodium (Na⁺)	40	65	65
Potassium (K⁺)	13	65	65
Magnesium (Mg⁺⁺)	3	10	10
Phosphorus (P)	3.5 (mM)^a	30 (mM)^a	30 (mM)^a
Chloride (Cl^–)	40	96^b	98^b
Acetate (C₂H₃O₂^–)	65^c	124^d	142^d
^{^a mM = millimoles; one mM of phosphorus = 31 mg. ^b Includes chloride from HCl added for processing and pH adjustment. ^c Includes acetate from acetic acid used in processing and the acetate salts of potassium, magnesium and lysine. ^d Includes acetate from acetic acid used in processing and from lysine acetate.}

Product Characteristics

Aminosyn	3.5% M*	7% WITH ELECTROLYTES	8.5% WITH ELECTROLYTES
Protein Equivalent (approx. grams/liter)	35	70	85
Total Nitrogen (grams/liter)	5.5	11.00	13.4
Specific Gravity	1.01	1.03	1.03
Osmolarity (mOsmol/liter)	421	883	1040
pH	5.2 (4.5—6.0)^e	5.2 (4.5 — 6.0)^f	5.2 (4.5 — 6.0)^f
^e Contains acetic acid for pH adjustment. ^f Contains hydrochloric acid and acetic acid for pH adjustment.

Electrolytes (mg/100 mL)

Aminosyn	3.5% M*
Sodium Chloride^g	234
Potassium Acetate^h	128
86.5% Phosphoric Acidⁱ	40
Magnesium Acetate, anhydrous^j	21
*Contains Maintenance Electrolytes

Aminosyn	7% WITH ELECTROLYTES	8.5% WITH ELECTROLYTES
Sodium Chloride^g	28	28
Magnesium Chloride, hexahydrate^k	102	102
Sodium Phosphate, dibasic^l	425	425
Potassium Chloride^m	487	487
^gSodium Chloride, USP is chemically designated NaCl, a white crystalline powder freely soluble in water. ^h Potassium Acetate, USP is chemically designated CH₃COOK, colorless crystals or white crystalline powder very soluble in water. ⁱ Phosphoric Acid 86.5%, NF is chemically designated H₃PO₄, a colorless, syrupy liquid miscible with water. ^j Magnesium Acetate is chemically designated magnesium acetate, tetrahydrate, Mg(CH₃COO)₂ • 4H₂O, colorless or white crystals very soluble in water. ^k Magnesium Chloride, USP is chemically designated magnesium chloride, hexahydrate, MgCl₂ • 6H₂O, deliquescent crystals very soluble in water. ^l Sodium Phosphate, dibasic, USP is chemically designated Na₂HPO₄, white granules very soluble in water. ^m Potassium Chloride, USP is chemically designated KCI, a white granular powder freely soluble in water.

The formulas for the individual amino acids present in Aminosyn are as follows:

Essential Amino Acids
Isoleucine, USP	(C₆H₁₃NO₂)
Leucine, USP	(C₆H₁₃NO₂)
Lysine Acetate, USP	(C₆H₁₄N₂O₂ • CH₃COOH)
Methionine, USP	(C₅H₁₁NO₂S)
Phenylalanine, USP	(C₉H₁₁NO₂)
Threonine, USP	(C₄H₉NO₃)
Tryptophan, USP	(C₁₁H₁₂N₂O₂)
Valine, USP	(C₅H₁₁NO₂)
Nonessential Amino Acids
Alanine, USP	(C₃H₇NO₂)
Arginine, USP	(C₆H₁₄N₄O₂)
Histidine, USP	(C₆H₉N₃O₂)
Proline, USP	(C₅H₉NO₂)
Serine, USP	(C₃H₇NO₃)
Tyrosine, USP	(C₉H₁₁NO₃)
Glycine, USP	(C₂H₅NO₂)

The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly.

Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.

Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.

Last reviewed on RxList: 1/14/2009
This monograph has been modified to include the generic and brand name in many instances.